The somatic mutation theory has been the prevailing paradigm in cancer research for the last 50 years. Its premises are: (1) cancer is derived from a single somatic cell that has accumulated multiple DNA mutations, (2) the default state of cell proliferation in metazoa is quiescence, and (3) cancer is a disease of cell proliferation caused by mutations in genes that control proliferation and the cell cycle. From this compelling simplicity, an increasingly complicated picture has emerged as more than 100 (...) oncogenes and 30 tumor suppressor genes have been identified. To accommodate this complexity, additional ad hoc explanations have been postulated. After a critical review of the data gathered from this perspective, an alternative research program has been proposed. It is based on the tissue organization field theory, the premises of which are that carcinogenesis represents a problem of tissue organization, comparable to organogenesis, and that proliferation is the default state of all cells. The merits of these competing theories are evaluated herein. BioEssays 26:1097–1107, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

How should nursing knowledge advance? This exploration contextualizes its evolution past and present. In addressing how it evolved in the past, a probable historical evolution of its development draws on the perspectives of Frank & Gills's World System Theory, Kuhn's treatise on Scientific Revolutions, and Foucault's notions of Discontinuities in scientific knowledge development. By describing plausible scenarios of how nursing knowledge evolved, I create a case for why nursing knowledge developers should adopt a post‐structural stance in prioritizing their research agenda(s). (...) Further, by adopting a post‐structural stance, I create a case on how nurses can advance their disciplinary knowledge using an engaging post‐colonial strategy. Given an interrupted history caused by influence(s) constraining nursing's knowledge development by power structures external, and internal, to nursing, knowledge development can evolve in the future by drawing on post‐structural interpretation, and post‐colonial strategy. The post‐structural writings of Deleuze & Guattari's understanding of ‘Nomadology’ as a subtle means to resist being constrained by existing knowledge development structures, might be a useful stance to understanding the urgency of why nursing knowledge should advance addressing the structural influences on its development. Furthermore, Bhabha's post‐colonial elucidation of ‘Hybridity’ as an equally discreet means to change the culture of those constraining structures is an appropriate strategy to enact how nursing knowledge developers can engage with existing power structures, and simultaneously influence that engagement. Taken together, ‘post‐structural stance’ and ‘post‐colonial strategy’ can refocus nursing scholarship to learn from its past, in order to develop relevant disciplinary knowledge in its future. (shrink)

I make a large claim for the intellectual and institutional centrality of the history of science as critical reason. The reality on the ground, of course, does not always exhibit this. I trace the vicissitudes of my own way of thought in relation to developments in the field, leading to an interest, first, in relating intellectual history (with its philosophical orientation) to mainstream (evidence based) history, and second, to finding a place for the human sciences in the history of science. (...) The latter area, which involves questioning the nature of science as knowledge, leads to an engagement with notions of being human. It is an interest which potentially makes the history of science a boundless field, and it is necessary to comment on the questions, both intellectual and practical, that this raises. I welcome a notion of the history of science as a family of activities, and I relate this to practices which seek models of good history rather than explicit methods. (shrink)

In Gray's conjecture, mismatches in the subicular comparator and matches have equal prominence in consciousness. In rival cognitive views novelty and difficulty especially elicit more conscious modes of cognition and higher levels of self-regulation. The mismatch between Gray's conjecture and these views is discussed.

In response to widespread doubts among professional philosophers (Russell, Horwich, Dietrich, McGinn, Chalmers), Stoljar argues for a ‘reasonable optimism’ about progress in philosophy. He defends the large and surprising claim that ‘there is progress on all or reasonably many of the big questions.’ However, Stoljar’s caveats and admitted avoidance of historical evidence permits overlooking persistent controversies in philosophy of mind and cognitive science that are essentially unchanged since the 17th Century. Stoljar suggests that his claims are commonplace in philosophy departments (...) and, indeed, the evidence I adduce constitutes an indictment of the widely shared view among professional analytic philosophers. (shrink)

The conception of reflective reasoning, like that of higher order thinking, has been informed by a Cartesian view of the self. Reflection is conceived of as a solipsistic process, in which persons consider their own thoughts in isolation. Higher order thinking has equally been represented as a single thinker considering thoughts at a meta-level. This paper proposes a different conception of reflection and higher order thinking, in which reflective dialogue is seen as the fundamental context in which reflection is possible (...) and higher order thinking engendered. The very process of dialectic defines what it is to be reflective and to think critically. Learning to reflect alone is a consequence of internalising the discourse. (shrink)

This article uses a reading of John Wesley's Primitive Physic, or An Easy and Natural Method of Curing Most Diseases (1747) to resist the common rejection—often as "quackery"—of Wesley's treatments for common maladies. We engage Wesley not because he was right but because his approach offers useful moments of pause in light of contemporary medical epistemology. Wesley's recommendations were primarily oriented towards the categories of personal responsibility and capability, but he also sought to empower individuals—especially the poor—with the knowledge to (...) safely and affordably treat maladies of their own. We leverage Primitive Physic to rethink contemporary medical knowledge production, especially as sanctioned by randomized clinical trials and legitimate views of experience and contemporary institutions such as the AMA. Ultimately, we suggest that the medical humanities has a key role to play in mining the discarded and dismissed for what they can tell scholars about medical knowledge. (shrink)

This article uses concepts from sociology, history, and philosophy to explore the shifting relationship between moral values and business in the Western world. We examine the historical roots and intellectual underpinnings of two major business-society paradigms in ideal-type terms. In pre-industrial Western society, we argue that business activity was linked to society’s values of morality (the moral unity paradigm}-for good or for ill. With the rise of industrialism, we contend that business was freed from moral constraints by the alleged “invisible (...) hand” of efficient markets (the amoral theory of business). Armed with this understanding of the intellectual history of the moral unity and amoral business-society paradigms, we suggest that some variant of the moral unity paradigm may be recurring in post-industrial society. (shrink)

This article uses concepts from sociology, history, and philosophy to explore the shifting relationship between moral values and business in the Western world. We examine the historical roots and intellectual underpinnings of two major business-society paradigms in ideal-type terms. In pre-industrial Western society, we argue that business activity was linked to society’s values of morality (the moral unity paradigm}-for good or for ill. With the rise of industrialism, we contend that business was freed from moral constraints by the alleged “invisible (...) hand” of efficient markets (the amoral theory of business). Armed with this understanding of the intellectual history of the moral unity and amoral business-society paradigms, we suggest that some variant of the moral unity paradigm may be recurring in post-industrial society. (shrink)

The paper seeks to answer two new questions about truth and scientific change: What lessons does the phenomenon of scientific change teach us about the nature of truth? What light do recent developments in the theory of truth, incorporating these lessons, throw on problems arising from the prevalence of scientific change, specifically, the problem of pessimistic meta-induction?

Gray's comparator model fails to provide an adequate explanation of consciousness for two reasons. First, it is based on a narrow definition of consciousness that excludes basic phenomenology and active functions of consciousness. Second, match/mismatch decisions can be made without producing an experience of consciousness. The model thus violates the sufficiency criterion.

Forty years’ experience as a bacterial geneticist has taught me that bacteria possess many cognitive, computational and evolutionary capabilities unimaginable in the first six decades of the twentieth century. Analysis of cellular processes such as metabolism, regulation of protein synthesis, and DNA repair established that bacteria continually monitor their external and internal environments and compute functional outputs based on information provided by their sensory apparatus. Studies of genetic recombination, lysogeny, antibiotic resistance and my own work on transposable elements revealed multiple (...) widespread bacterial systems for mobilizing and engineering DNA molecules. Examination of colony development and organization led me to appreciate how extensive multicellular collaboration is among the majority of bacterial species. Contemporary research in many laboratories on cell–cell signaling, symbiosis and pathogenesis show that bacteria utilise sophisticated mechanisms for intercellular communication and even have the ability to commandeer the basic cell biology of ‘higher’ plants and animals to meet their own needs. This remarkable series of observations requires us to revise basic ideas about biological information processing and recognise that even the smallest cells are sentient beings. (shrink)

How should sociologists use the word theory? Gabriel Abend’s recent insistence that this question should be tackled politically raises two important issues: Is sociology political? And if so, what normative implications follow for its organization? Drawing on Wittgenstein’s notion of family resemblance and post-Gramscian theories of hegemony, I argue that Abend’s proposal that semantic questions about theory can be addressed separately from ontological, evaluative, and teleological ones is untenable. Disagreements about the latter are constitutive, not merely supplementary to the meaning (...) of theory. Against Abend’s deliberative-democratically oriented vision, I propose an agonistic politics of theory. In doing so, I consider both the internal inconsistencies of deliberativism and the practical advantages and sociological relevance of agonism. (shrink)

In the cognitive stage of religious traditions, science, in the light of the authority of religious revelation and reason, was dominant in relation to culture, which means that it was possible to determine the true value of different cultures using scientific knowledge. Nowadays, the completely opposite approach is gaining in popularity. Namely, when they discovered the fundamental weaknesses of empiristic definition of science, postmodern philosophers started more vocally saying that culture actually has a crucial influence on the method and internal (...) science structure. Thus, science loses its cognitive independence and becomes the product of culture. In other words, each culture creates a separate scientific knowledge in accordance with its other cognitive layers and needs of the members of that culture. Among the Muslim reformist thinkers, influential Nasr Hamid Abu Zayd wrote in a most comprehensive and thorough manner about the text of the Quran undergoing the influence of culture from the time of life of t he Prophet Muhammad. He explained that the interpreter necessarily has a crucial role in forming the meaning of a text and that the meaning of the text will not be determined on its own until the hermeneutical position of the person reading and interpreting it is taken into consideration. Abu Zayd believed that the primal meaning of the Quran was conditioned by cultural and historic contexts of the time when the Quran appeared and that meaning was no longer credible. However, according to his opinion, the essence of the Quran message will be discovered using hermeneutics, when we harmonize the text with our contemporary cultural realities. With his pioneering attitude, Abu Zayd broke all ontological and metaphysical principles of mystical hermeneutics in the traditional cognitive environment of Islam. The renowned representatives of Islamic mystical heritage insisted that essential and inner meanings of the Quran text are in no way opposing its outer meaning. Using various methods, they uncovered sophisticated secrets of the Quran teachings in the heart of outer layer of the words of God and, in that manner, they ascended to the heaven of metaphysical realities of the Quran and the whole universe. (shrink)

Calling for an expanded framework of EuroAmerican science's methodology whose perspective acknowledges both quantitative/etic and qualitative/emic orientations is the broad focus of this article. More specifically this article argues that our understanding of shamanic and/or other related states of consciousness has been greatly enhanced through ethnographic methods, yet in their present form these methods fail to provide the means to fully comprehend these states. They fail, or are limited, because this approach is only a “cognitive interpretation” or “metanarrative” of the (...) actual experience and not the experience itself. Consequently this perspective is also limited because the researcher continues to assess his or her data through the lens of their symbolic constructs, thereby preventing them from truly experiencing shamanic and psi/spirit approaches to knowing since the data collection process does not “in and of itself” affect the observer. We, therefore, need expanded ethnographic methods that include within their approaches an understanding of methods and techniques to experientially encounter these states of consciousness—and become transformed by them. Our becoming transformed and then recollecting our ethnoautobiographical experiences is the means toward a new kind of science and its methods of inquiry that this article seeks to encourage. (shrink)

Some philosophers hold that the neuroscience of action is, in practice or in principle, incapable of touching debates in action theory and moral psychology. The role of desires in action, the existence of basic actions, and the like are topics that must be sorted out by philosophers alone: at least at present, and perhaps by the very nature of the questions. This paper examines both philosophical and empirical arguments against the relevance of neuroscience to such questions and argues that neither (...) succeeds. In practice, there is already a stable body of findings from neuroanatomy and neurophysiology that warrants attention. And as a matter of principle, the ‘causal map’ of action production derivable from these findings requires the study of action theorists and moral psychologists because every such philosopher has commitments to the shape of this causal map: commitments that might be in conflict with reality. (shrink)

This article describes abductions as special patterns of inference to the best explanation whose structure determines a particularly promising abductive conjecture and thus serves as an abductive search strategy. A classification of different patterns of abduction is provided which intends to be as complete as possible. An important distinction is that between selective abductions, which choose an optimal candidate from given multitude of possible explanations, and creative abductions, which introduce new theoretical models or concepts. While selective abduction has dominated the (...) literature, creative abductions are rarely discussed, although they are essential in science. The article introduces several kinds of creative abductions, such as theoretical model abduction, common cause abduction and statistical factor analysis, and illustrates them by various real case examples. It is suggested to demarcate scientifically fruitful abductions from purely speculative abductions by the criterion of causal unification. (shrink)

Although postmodernist thought has become prominent in some educational circles, its influence on science education has until recently been rather minor. This paper examines the proposal of Michalinos Zembylas, published earlier in this journal, that Lyotardian postmodernism should be applied to science educational reform in order to achieve the much sought after positive transformation. As a preliminary to this examination several critical points are raised about Lyotard's philosophy of education and philosophy of science which serve to challenge and undermine Zembylas’ (...) project. Subsequently, the three main theses of Lyotard that Zembylas considers beneficial and wishes to transpose onto science classrooms and pedagogy are scrutinized and found to be more of a hindrance than a help to curriculum reformers. (shrink)

In his commentary on my paper, “Means-Ends Epistemology”, David Chart constructs a Riddle of Induction with the following feature: Means-ends analysis, as I formulated it in the paper, selects “all emeralds are grue” as the optimal conjecture after observing a sample of all green emeralds. Chart’s construction is rigorous and correct. If we disagree, it is in the philosophical morals to be drawn from his example. Such morals are best discussed by elucidating some of the larger epistemological issues involved. “Means-ends (...) Epistemology” sought a normative theory of hypothesis selection. I defined what it means for an inductive method to reliably and efficiently find a correct hypothesis from a set of alternative hypotheses. (In fact, I investigated a number of standards of empirical success for inductive methods.) Call such methods optimal. We may take optimal inferences to be those made by optimal methods. This defines a relation Optimal-Inference(h,e,H): “given the set of alternative hypotheses H, and evidence e, hypothesis h is an optimal inference”. One fundamental difference between the means-ends approach and traditional confirmation theory is that the latter has sought a two-place relation between theory and evidence alone, something like “hypothesis h is highly confirmed given evidence e”. From my point of view, posing the problem of induction as discerning the right relation between theory and evidence is elliptical because it leaves unspecified the set of alternative hypotheses under investigation (as well as other relevant factors, such as the scientist’s background knowledge, observational means, cognitive capacities and epistemic values). Chart’s Riddle highlights the fact that depending on the space of alternative hypotheses, means-ends analysis may select a different hypothesis on the same evidence: “all emeralds are green” in my Goodmanian Riddle, and “all emeralds are grue” in his. To my mind, his example.. (shrink)

The doctrine of eliminative materialism holds that belief-desire psychology is massively referentially disconnected. We claim, however, that it is not at all obvious what it means to be referentially (dis)connected. The two major accounts of reference both lead to serious difficulties for eliminativism: it seems that elimination is either impossible or omnipresent. We explore the idea that reference fixation is a much more local, partial, and context-dependent process than was supposed by the classical accounts. This pragmatic view suggests that elimination (...) is not the prime model for understanding the complex relations between the mind and brain sciences, and that we have little ground for concluding that in general psychological kinds do not exist. We suggest that reference changes are better seen as continuous rather than completely eliminative. (shrink)

This article looks at recent work in cognitive science on mathematical cognition from the perspective of history and philosophy of mathematical practice. The discussion is focused on the work of Lakoff and Núñez, because this is the first comprehensive account of mathematical cognition that also addresses advanced mathematics and its history. Building on a distinction between mathematics as it is presented in textbooks and as it presents itself to the researcher, it is argued that the focus of cognitive analyses of (...) historical developments of mathematics has been primarily on the former, even if they claim to be about the latter. (shrink)

The communicative aspects of the contents of consciousness are analyzed in the framework of a neural network model of animal communication. We discuss some issues raised by Gray, such as the control of the contents of consciousness, the adaptive value of consciousness, conscious and unconscious behaviors, and the nature of a model's consciousness.

Psychologists investigating dreams in non-Western cultures have generally not considered the meanings of dreams within the unique meaning-structure of the person in his or her societal context. The study was concerned with explicating the indigenous system of dream interpretation of the Xhosa-speaking people, as revealed by acknowledged dream experts, and elaborating upon the life-world of the participants. Fifty dreams and their interpretations were collected from participants, who were traditional healers and their clients. A phenomenological methodology was adopted in explicating the (...) data. Themes explicated included : the physiognomy of the dreamer's life-world as revealed by significant dreams, the interpretation of significant dreams as revealed through action, and human bodiliness as revealed in dream interpretations. The participants' approach to dreams is not based upon an explicit theory, but upon an immediate and pathic understanding of the dream phenomenon. The understanding is based upon the interpreter's concrete understanding of the life-world, which includes the possibility of cosmic integration and continuity between personal and trans-personal realms of being. (shrink)

Words change meaning over time. Some meaning shift is accompanied by a corresponding change in subject matter; some meaning shift is not. In this paper I argue that an account of linguistic meaning can accommodate the first kind of case, but that a theory of concepts is required to accommodate the second. Where there is stability of subject matter through linguistic change, it is concepts that provide the stability. The stability provided by concepts allows for genuine disagreement and ameliorative change (...) in the context of conceptual engineering. (shrink)

The postmodern enterprise, with its foundationlessness, fragmentariness, constructivism, and neopragmatism challenges interdisciplinarity. This paper discusses functional specialization and interdisciplinary method which provides a basis for interdisciplinary collaboration. In functional specialization, successive stages in the process of coming to know are distinguished. These stages correspond to Lonergan’s four levels of consciousness, namely experiencing the data, coming to understanding through addressing questions which arise from the data, and judgment about which hypothesis best fits the data. Authenticity, which involves genuine attentiveness, intelligence, reasonableness, (...) and responsibility, guides the appropriate attitude in interdisciplinary work. (shrink)

This volume is the record of a symposium on the structer of scientific theories held in urbana, Illinois in the spring of 1969. ofSeven main papers, commentaries, discussions, and a postscript form the bulk of the book. The rest is a nearly 240-page monograph-in-the-guise-of-an-introduction by the editor titled “The Search for Philosophic Understanding of Scientific Theories”.

In terms of output in the form of published work and attraction of resources, bioethics seems to be a more vibrant field than environmental ethics. In this commentary it is argued that bioethics is, in some respect, less humanistic than environmental ethics and that two factors––bioethics’ strong connection to a profession, and its access to an intellectual ‘killer app’––offer ways in which environmental ethicists might learn from the ‘success story’ of bioethics.