In psychiatry, pharmacological drugs play an important experimental role in attempts to identify the neurobiological causes of mental disorders. Besides being developed in applied contexts as potential treatments for patients with mental disorders, pharmacological drugs play a crucial role in research contexts as experimental instruments that facilitate the formulation and revision of neurobiological theories of psychopathology. This paper examines the various epistemic functions that pharmacological drugs serve in the discovery, refinement, testing, and elaboration of neurobiological theories of mental disorders. I (...) articulate this thesis with reference to the history of antipsychotic drugs and the evolution of the dopamine hypothesis of schizophrenia in the second half of the twentieth century. I argue that interventions with psychiatric patients through the medium of antipsychotic drugs provide researchers with information and evidence about the neurobiological causes of schizophrenia. This analysis highlights the importance of pharmacological drugs as research tools in the generation of psychiatric knowledge and the dynamic relationship between practical and theoretical contexts in psychiatry. (shrink)

I investigate a new understanding of realism in science, referred to as ‘interactive realism’, and I suggest the ‘evolutionary progressiveness’ of a theory as novel criterion for this kind of realism. My basic claim is that we cannot be realists about anything except the progress affected by myriad science-reality interactions that are constantly moving on a continuum of increased ‘fitness’ determined according to empirical constraints. Moreover to reflect this movement accurately, there is a corresponding continuum of verdicts about the status (...) of the knowledge conveyed by theories – ranging from stark instrumentalism to full-blown realism. This view may sound like a pessimistic inductivist's dream, but actually this is so only if one evaluates it from within a traditional context where the ‘truth’ of a single theory is the exclusive criterion for realism. I, on the other hand, want to redefine the terms of realist debate in such a way that the units of assessment of realism are sequences of theories evaluated according to their ‘evolutionary progressiveness’. I unpack ‘interactive realism’ by defining my notion of ‘evolutionary progressiveness’, the notion of ‘truth-as-historied reference’ underpinning it, and the continuum of interaction between theories and aspects of reality it affects. I conclude that, although interactive realism is a radically non-standard kind of realism, it is at least more realistic about science as a fractured complex multi-faceted enterprise than most other kinds of realism on the block, because it shows coherence amidst fragmentation. (shrink)

Contrary to the assumptions of empiricist philosophies of science, the theory-laden character of data will not imply the inherent failure (subjectivity, circularity, or rationalization) of instruments to expose nature's secrets. The success of instruments is credited to scientists' capacity to create artificial technological analogs to familiar physical systems. The design of absorption spectrometers illustrates the point: Progress in designing many modern instruments is generated by analogically projecting theoretical insights from known physical systems to unknown terrain. An experimental realism is defended.

In Extragalactic Reality: The Case of Gravitational Lensing Hacking resumes the discussion of scientific realism from the last chapter of Representing and Intervening. Since the criterion of manipulability cannot be applied to astronomical objects, experimental entity realism seems to be restricted to terrestrial entities. In fact, Hacking explicitly argues against astronomical realism. The case at issue is the existence of gravitational lenses. In this paper, I question Hacking 's chief witness for astronomical antirealism: the gravitational lens system “0957+ 561”. It (...) will be shown that Hacking 's argumentation is misleading. Discussing astronomical realism as theory realism, Hacking focuses on the question of how to infer the existence of gravitational lenses from the truth of gravitational lens theory. But neither the reconstruction of gravitational lensing in terms of inference to the best explanation nor the argument of underdetermination are tenable under closer inspection. My thesis is that a realist account of gravitational lensing can be given by relying on observation, causal capacities and home truths. (shrink)

As Laudan and Fine show, and Boyd concedes, the attempt to infer the truth of scientific realism from the fact that it putatively provides the best explanation of the instrumental success of science is circular, since what is to be shown is precisely the legitimacy of such abductive inferences. Hacking's "experimental argument for scientific realism about entities" is one of the few arguments for scientific realism that purports to avoid this circularity. We argue that Hacking's argument is as dependent on (...) inference to the best explanation (IBE), and therefore as weak, as the other realist arguments. (shrink)

Entity realism is the view that ‘a good many theoretical entities do really exist’. The main novelty of entity realism was that it provided an account of scientific realism that did not have to endorse realism about theories—the general proposal was that entity realism is noncommittal about whether we should be realist about scientific theories. I argue that the only way entity realists can resist the pull of straight scientific realism about theories is by endorsing a recent new player in (...) the scientific realism debate: singularist semirealism. (shrink)

The concept of mental representation has long been considered to be central concept of philosophy of mind and cognitive science. But not everyone agrees. Neo-behaviorists aim to explain the mind without positing any representations. My aim here is not to assess the merits and demerits of neo-behaviorism, but to take their challenge seriously and ask the question: What justifies the attribution of representations to an agent? Both representationalists and neo-behaviorists tend to take it for granted that the real question about (...) representations is whether we should be realist about the theory of representationalism. This paper is an attempt to shift the emphasis from the debate concerning realism about theories to the one concerning realism about entities. My claim is that regardless of whether we are realist about representational theories of the mind, we have compelling reasons to endorse entity realism about mental representations. (shrink)

One of Nancy Cartwright's arguments for entity realism focuses on the non-redundancy of causal explanation. In How the Laws of Physics Lie she uses an example from laser theory to illustrate how we can have a variety of theoretical treatments governing the same phenomena while allowing just one causal story. In the following I show that in the particular example Cartwright chooses causal explanation exhibits the same kind of redundancy present in theoretical explanation. In an attempt to salvage Cartwright's example (...) the causal explanation could be reinterpreted as a capacity claim, as outlined in her recent work Nature's Capacities and Their Measurement. However, I argue that capacities cannot be isolated in the way that Cartwright suggests and consequently these capacity claims also fail to provide a unique causal story. We can, however, make sense of capacities by characterizing them in a relational way and I offer some ideas as to how this approach would retain our intuitions about capacities while denying their ontological priority as dormant powers. (shrink)

According to Ian Hacking’s Entity Realism, unobservable entities that scientists carefully manipulate to study other phenomena are real. Although Hacking presents his case in an intuitive, attractive, and persuasive way, his argument remains elusive. I present five possible readings of Hacking’s argument: a no-miracle argument, an indispensability argument, a transcendental argument, a Vichian argument, and a non-argument. I elucidate Hacking’s argument according to each reading, and review their strengths, their weaknesses, and their compatibility with each other.

The anti-metaphysical argument against scientific realism is the following: Knowledge of unobservable entities implies metaphysical knowledge; There is no metaphysical knowledge. Therefore, there is no knowledge of unobservable entities. This argument has strangely received little attention in the profuse literature on scientific realism. This paper claims that the AMA is logically more fundamental than both the pessimistic meta-induction and the underdetermination argument. The second and main claim of this paper is that the instrumentalists’ use of AMA is incoherent. The gist (...) of my argument is that experimental knowledge requires minimally metaphysical knowledge, and that minimally metaphysical knowledge—when associated with empirical knowledge—suffices to yield a minimal knowledge of the unobservable. I then examine and reject two possible responses: minimally metaphysical instrumentalism and algebraic instrumentalism. (shrink)

In many scientific fields, today’s practices of empirical enquiry rely heavily on the production of images that display the investigated phenomena. And while scientific images of phenomena have been important for a long time, what is striking now is that scientists have found ways to visualize such widely different types of phenomena. In the past twenty or thirty years, we have become accustomed to seeing images of galaxies, of cells, of the human brain but also of blood flow or of (...) turbulent fluids. This success in making images relies first on the set of imaging devices that have flourished in the twentieth century, instruments such as radio-telescopes, electronic microscopes, MRI and many more. Without these... (shrink)

The goal of this paper is to defend the claim that there is such a thing as direct perception, where by ‘direct perception’ I mean perception unmediated by theorizing or concepts. The basis for my defense is a general philosophic perspective which I call ‘empiricist philosophy’. In brief, empiricist philosophy (as I have defined it) is untenable without the occurrence of direct perception. It is untenable without direct perception because, otherwise, one can't escape the hermeneutic circle, as this phrase is (...) used in van Fraassen (1980). The bulk of the paper is devoted to defending my belief in direct perception against various objections that can be posed against it. I discuss various anticipations of my view found in the literature, eventually focusing on Ian Hacking's related conception of `entity realism' (Hacking 1983). Hacking has been criticized by a number of philosophers and my plan is to respond to these criticisms on behalf of entity realism (or more precisely on behalf of the claim that direct perception is a reality) and to then respond to other possible criticisms that can be launched against direct perception. (shrink)

In its original form due to Ian Hacking, entity realism postulates a criterion of manipulative success which replaces explanatory virtue as the criterion of justified scientific belief. The article analyses the foundations on which this postulate rests and identifies the conditions on which one can derive a form of entity realism from it. It then develops in detail an extensive class of counterexamples, drawing on the notion of quasi-particles in condensed matter physics. While the phenomena associated with quasi-particles pass the (...) entity realist's criterion of manipulative success, quasi-particles themselves are illusions, and can be seen to be so even on the basis of the largely non-theoretical "home truths" that one must be ready to admit as background knowledge. Hence, Hacking's entity realism is shown to be incoherent. (shrink)

The philosophy of science community mourns the loss of Margaret Catherine Morrison, who passed away on January 9, 2021, after a long battle with cancer. Margie, as she was known to all who knew her, was highly regarded for her influential contributions to the philosophy of science, particularly her studies of the role of models and simulations in the natural and social sciences. These contributions made her a world-leading philosopher of science, instrumental in shifting philosophers' attention from the structure of (...) scientific theories to the practice of science. Her sophisticated studies of the function of models in scientific practice drew on detailed knowledge of the theories and experiments of physics as well as the history of physics. In emphasizing the autonomy of scientific models and their interventional character, her insights had some affinity with Cartwright's and Hacking’s views on phenomenological laws, entity realism, the instrumentalist interpretation of scientific theories, and the disunity of science. But Morrison’s approach was distinguished by the conviction that the existence of unobservable entities cannot be defended independently of the theories that support their evidence, and that scientific practice cannot be adequately understood without examining the reasons for theory unification. (shrink)

Although scientific realism is the default position in the life sciences, philosophical accounts of realism are geared towards physics and run into trouble when applied to fields such as biology or neuroscience. In this paper, I formulate a new robustness-based version of entity realism, and show that it provides a plausible account of realism for the life sciences that is also continuous with scientific practice. It is based on the idea that if there are several independent ways of measuring, detecting (...) or deriving something, then we are justified in believing that it is real. I also consider several possible objections to robustness-based entity realism, discuss its relationship to ontic structural realism, and show how it has the potential to provide a novel response to the pessimistic induction argument. (shrink)

Life-science phenomena are often explained by specifying the mechanisms that bring them about. The new mechanistic philosophers have done much to substantiate this claim and to provide us with a better understanding of what mechanisms are and how they explain. Although there is disagreement among current mechanists on various issues, they share a common core position and a seeming commitment to some form of scientific realism. But is such a commitment necessary? Is it the best way to go about mechanistic (...) explanation? In this article, we propose an alternative antirealist account that also fits explanatory practice in the life sciences. We pay special attention to mechanistic models, i.e. scientific models that involve a mechanism, and to the role of coherence considerations in building such models. To illustrate our points, we consider the mechanism for the action potential. 1 Introduction2 Some Core Features of Mechanistic Explanation3 Scientific Realism and Mechanistic Explanation4 Antirealist Mechanistic Explanation: The Case of the Action Potential5 Some Outstanding Issues for the Antirealist Mechanist6 Two Problems for the Realist Mechanist7 Conclusions. (shrink)

This paper discusses an argument for scientific realism put forward by Anthony Quinton in The Nature of Things. The argument – here called the controlled continuity argument – seems to have received no attention in the literature, apparently because it may easily be mistaken for a better-known argument, Grover Maxwell’s “argument from the continuum”. It is argued here that, in point of fact, the two are quite distinct and that Quinton’s argument has several advantages over Maxwell’s. The controlled continuity argument (...) is also compared to Ian Hacking’s “argument from coincidence”. It is pointed out that both arguments are to a large extent independent from considerations about high-level scientific theories, and that both are abductive arguments at the core. But these similarities do not dilute an important difference related to the fact that Quinton’s argument cleverly seeks to anchor belief in unobservable entities in realism about ordinary objects, which is a position shared by most contemporary scientific anti-realists. (shrink)

Structural realism has recently re-entered mainstream discussions in the philosophy of science. The central notion of structure, however, is contested by both advocates and critics. This paper briefly reviews currently prominent structuralist accounts en route to proposing a metaphysics of structure that is capable of supporting the epistemic aspirations of realists, and that is immune to the charge most commonly levelled against structuralism. This account provides an alternative to the existing epistemic and ontic forms of the position, incorporating elements of (...) both. Structures are here identified with relations between first order, causal properties: properties that confer specific dispositions for relations. This form of structuralism constitutes an explicit proposal for what seem implicit structuralist tendencies in sophisticated but more traditional characterizations of realism. An outline of the proposal's response to the anti-realist's pessimistic induction on the history of scientific theories is considered. (shrink)

This paper tells the story of G-protein coupled receptors, one of the most important scientific objects in contemporary biochemistry and molecular biology. By looking at how cell membrane receptors turned from a speculative concept into a central element in modern biochemistry over the past 40 years, we revisit the role of manipulability as a criterion for entity realism in wet-lab research. The central argument is that manipulability as a condition for reality becomes meaningful only once scientists have decided how to (...) conceptually coordinate measurable effects distinctly to a specific object. We show that a scientific entity, such as GPCRs, is assigned varying degrees of reality throughout different stages of its discovery. The criteria of its reality, we further claim, cannot be made independently of the question about how this object becomes a standard by which the reality of neighbouring elements of enquiry is evaluated. (shrink)

In this chapter I investigate the prospects of integrated history and philosophy of science, by examining how philosophical issues raised by “hidden entities”, entities that are not accessible to unmediated observation, can enrich the historical investigation of their careers. Conversely, I suggest that the history of those entities has important lessons to teach to the philosophy of science. Hidden entities have played a crucial role in the development of the natural sciences. Despite their centrality to past scientific practice, however, several (...) of them (e.g., phlogiston, caloric, and the ether) turned out to be fictitious. For this reason, they have figured prominently in recent debates on scientific realism. The issues I explore in this paper are entangled with those debates. I argue that our understanding of hidden entities and their role in experimental practice can be enhanced by adopting an integrated historical-cum-philosophical approach. On the one hand, philosophical reflection on the reality of those entities has a lot to gain by examining historically how they were ntroduced and investigated. On the other hand, the historical reconstruction of the careers of those entities may profit from philosophical reflection on their existence. (shrink)

In this paper I address some of the problems that the historical development of science poses for a realist and discuss whether a realist construal of scientific activity is conducive to historiographical practice. First, I discuss, by means of historical examples, Ian Hacking's defense of entity realism. Second, I try to show, drawing on Kuhn's recent work on incommensurability, that the realism problem is relevant to historiography and that a realist position entails a particular historiographical strategy, which faces problems. Finally, (...) I suggest that for historiographical purposes an agnostic attitude with respect to scientifictheories and unobservable entities is the most appropriate. (shrink)

On a purely epistemic understanding of experimental realism, manipulation affords a particularly robust kind of causal warrant, which is – like any other warrant – defeasible. I defend a version of Nancy Cartwright’s inference to the most likely cause, and I conclude that this minimally epistemic version of experimental realism is a coherent, adequate and plausible epistemology for science.

Debates about scientific realism are closely connected to almost everything else in the philosophy of science, for they concern the very nature of scientific knowledge. Scientific realism is a positive epistemic attitude toward the content of our best theories and models, recommending belief in both observable and unobservable aspects of the world described by the sciences. This epistemic attitude has important metaphysical and semantic dimensions, and these various commitments are contested by a number of rival epistemologies of science, known collectively (...) as forms of scientific antirealism. This article explains what scientific realism is, outlines its main variants, considers the most common arguments for and against the position, and contrasts it with its most important antirealist counterparts. (shrink)

(i) Scientific realism is primarily a metaphysical doctrine about the existence and nature of the unobservables of science. (ii) There are good explanationist arguments for realism, most famously that from the success of science, provided abduction is allowed. Abduction seems to be on an equal footing, at least, with other ampliative methods of inference. (iii) We have no reason to believe a doctrine of empirical equivalence that would sustain the underdetermination argument against realism. (iv) The key to defending realism from (...) the pessimistic meta-induction is that we have greatly improved our capacity to understand the unobservable world over recent centuries. (shrink)

This dissertation is about human knowledge of reality. In particular, it argues that scientific knowledge is bounded by historically available instruments and theories; nevertheless, the use of several independent instruments and theories can provide access to the persistent potentialities of reality. The replicability of scientific observations and experiments allows us to obtain explorable evidence of robust entities and properties. The dissertation includes seven chapters. It also studies three cases – namely, Higgs bosons and hypothetical Ϝ-particles (section 2.4), the Ptolemaic and (...) Kepler model of the planets (section 6.7), and the special theory of relativity (chapter 7). -/- Chapter 1 is the introduction of the dissertation. Chapter 2 clarifies the notion of the real on the basis of two concepts: persistence and resistance. These concepts enable me to explain my ontological belief in the real potentialities of human-independent things and the implications of this view for the perceptual and epistemological levels of discussion. On the basis of the concept of “overlapping perspectives”, chapter 3 argues that entity realism and perspectivism are complementary. That is, an entity that manifests itself through several experimental/observational methods is something real, but our knowledge of its nature is perspectival. Critically studying the recent views of entity realism, chapter 4 extends the discussion of entity realism and provides a criterion for the reality of property tokens. Chapter 5, in contrast, develops the perspectival aspects of my view on the basis of the phenomenological-hermeneutical approaches to the philosophy of science. This chapter also elaborates my view of empirical evidence, as briefly expressed in sections 2.5 and 4.5. Chapter 6 concerns diachronic theoretical perspectives. It first explains my view of progress, according to which current perspectives are broader than past ones. Second, it argues that the successful explanations and predictions of abandoned theories can be accounted for from our currently acceptable perspectives. The case study of Ptolemaic astronomy supports the argument of this chapter. Chapter 7 serves as the conclusion of the dissertation by applying the central themes of the previous chapters to the case study of special relativity theory. I interpret frame-dependent properties, such as length and time duration, and the constancy of the speed of light according to realist perspectivism. (shrink)

Laboratory experimentation was once considered impossible or irrelevant in economics. Recently, however, economic science has gone through a real ‘laboratory revolution’, and experimental economics is now a most lively subfield of the discipline. The methodological advantages and disadvantages of controlled experimentation constitute the main subject of this thesis. After a survey of the literature on experiments in philosophy and economics, the problem of testing normative theories of rationality is tackled. This philosophical issue was at the centre of a famous controversy (...) in decision theory, during which a methodology of normative falsification was first articulated and used to assess experimental results. In the third chapter, the methodological advantages of controlled experimentation are illustrated and discussed with examples taken from the experiments on the so-called ‘preference reversal’ phenomenon. Laboratory testing allows to establish with a high degree of certainty that certain phenomena lie behind the experimental data, by means of independent testing, elimination of alternative hypotheses, and the use of different instruments of observation. The fourth chapter is devoted to a conceptual analysis of the problem of ‘parallelism’. This is the problem of inferring from the occurrence of a phenomenon in the laboratory, to its instantiation also in non-laboratory environments. Experimental economists have discussed parallelism at length, and their views are presented and criticised. Eventually, it is argued that parallelism is a factual matter and as such can only be established on empirical grounds. The fifth chapter provides an example of how one can argue for parallelism, focusing on the case of experimentation on the ‘winner’s curse’ phenomenon. The role of experiments as ‘mediators’ between theoretical models and their target domain of application is illustrated, and the structure of parallelism arguments analysed in detail. Finally, in the last chapter, economic experiments are compared to simulations, in order to highlight their specific characteristics. (shrink)

In this paper I investigate the prospects of integrated history and philosophy of science, by examining how philosophical issues concerning experimental practice and scientific realism can enrich the historical investigation of the careers of "hidden entities", entities that are not accessible to unmediated observation. Conversely, I suggest that the history of those entities has important lessons to teach to the philosophy of science. My overall aim is to illustrate the possibility of a fruitful two-way traffic between history and philosophy of (...) science. (shrink)