Switch to: References

Add citations

You must login to add citations.
  1. Mitochondrial replacement techniques for treating infertility.Esther Braun - forthcoming - Journal of Medical Ethics.
    Mitochondrial replacement techniques (MRTs) usually aim to prevent the genetic transmission of maternally inherited mitochondrial diseases. Until now, only the UK and Australia have implemented specific legal regulations of MRTs. In both countries, clinical trials on these techniques are only permissible for cases with a high risk of severe mitochondrial disease in the offspring. However, these techniques can also be applied to treat infertility, especially for older women with impaired oocyte quality. In some countries without legal regulation of these techniques, (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  • Mitochondrial Replacement Techniques, the Non-Identity Problem, and Genetic Parenthood.William Simkulet - 2021 - Asian Bioethics Review 13 (3):317-334.
    Mitochondrial replacement techniques are designed to allow couples to have children without passing on mitochondrial diseases. Recently, Giulia Cavaliere and César Palacios-González argued that prospective parents have the right to use MRTs to pursue genetic relatedness, such that some same-sex couples and/or polygamous triads could use the process to impart genetic relatedness between a child and more of its caregivers. Although MRTs carry medical risks, Cavaliere and Palacios-González contend that because MRTs are identity-affecting, they do not cause harm to an (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  • The need for donor consent in mitochondrial replacement.G. Owen Schaefer - 2018 - Journal of Medical Ethics 44 (12):825-829.
    Mitochondrial replacement therapy requires oocytes of women whose mitochondrial DNA will be transmitted to resultant children. These techniques are scientifically, ethically and socially controversial; it is likely that some women who donate their oocytes for general in vitro fertilisation usage would nevertheless oppose their genetic material being used in MRT. The possibility of oocytes being used in MRT is therefore relevant to oocyte donation and should be included in the consent process when applicable. In present circumstances, specific consent should be (...)
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  • Does egg donation for mitochondrial replacement techniques generate parental responsibilities?César Palacios-González - 2018 - Journal of Medical Ethics 44 (12):817-822.
    Children created through mitochondrial replacement techniques (MRTs) are commonly presented as possessing 50% of their mother’s nuclear DNA, 50% of their father’s nuclear DNA and the mitochondrial DNA of an egg donor. This lab-engineered genetic composition has prompted two questions: Do children who are the product of an MRT procedure have threegeneticparents? And, do MRT egg donors have parental responsibilities for the children created? In this paper, I address the second question and in doing so I also address the first (...)
    Direct download (9 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  • Genome Modifying Reproductive Procedures and their Effects on Numerical Identity.Calum MacKellar - 2019 - The New Bioethics 25 (2):121-136.
    The advantages and risks of a number of new genome modifying procedures seeking to create healthy or enhanced individuals, such as Maternal Spindle Transfer, Pronuclear Transfer, Cytoplasmic Transfer and Genome Editing, are currently being assessed from an ethical perspective, by national and international policy organizations. One important aspect being examined concerns the effects of these procedures on different kinds of identity. In other words, whether or not a procedure only modifies the qualities or properties of an existing human being, meaning (...)
    No categories
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  • Lesbian motherhood and mitochondrial replacement techniques: reproductive freedom and genetic kinship.Giulia Cavaliere & César Palacios-González - 2018 - Journal of Medical Ethics 44 (12):835-842.
    In this paper, we argue that lesbian couples who wish to have children who are genetically related to both of them should be allowed access to mitochondrial replacement techniques. First, we provide a brief explanation of mitochondrial diseases and MRTs. We then present the reasons why MRTs are not, by nature, therapeutic. The upshot of the view that MRTs are non-therapeutic techniques is that their therapeutic potential cannot be invoked for restricting their use only to those cases where a mitochondrial (...)
    Direct download (9 more)  
     
    Export citation  
     
    Bookmark   19 citations  
  • Genome editing and assisted reproduction: curing embryos, society or prospective parents?Giulia Cavaliere - 2018 - Medicine, Health Care and Philosophy 21 (2):215-225.
    This paper explores the ethics of introducing genome-editing technologies as a new reproductive option. In particular, it focuses on whether genome editing can be considered a morally valuable alternative to preimplantation genetic diagnosis. Two arguments against the use of genome editing in reproduction are analysed, namely safety concerns and germline modification. These arguments are then contrasted with arguments in favour of genome editing, in particular with the argument of the child’s welfare and the argument of parental reproductive autonomy. In addition (...)
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark   24 citations  
  • Genetic ethics and mtDNA replacement techniques.Courtney A. Brenner - 2021 - The New Bioethics 27 (1):3-18.
    1. The field of genetics has seen a huge increase in advancements over the past decade. Diseases that were once considered to have no treatment options yielding dismal outcomes now have quick and e...
    No categories
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
    		•
  • Mitochondrial Replacement Techniques: Genetic Relatedness, Gender Implications, and Justice.César Palacios-González & Tetsuya Ishii - 2017 - Gender and the Genome 1 (4):1-6.
    In 2015 the United Kingdom (UK) became the first nation to legalize egg and zygotic nuclear transfer procedures using mitochondrial replacement techniques (MRTs) to prevent the maternal transmission of serious mitochondrial DNA diseases to offspring. These techniques are a form of human germline genetic modification and can happen intentionally if female embryos are selected during the MRT clinical process, either through sperm selection or preimplantation genetic diagnosis (PGD). In the same year, an MRT was performed by a United States (U.S.)-based (...)
    Direct download  
     
    Export citation  
     
    Bookmark  
    		•