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  1. Dynamic network rewiring determines temporal regulatory functions in Drosophilamelanogaster development processes.Man-Sun Kim, Jeong-Rae Kim & Kwang-Hyun Cho - 2010 - Bioessays 32 (6):505-513.
    Cover Photograph: Resolving developmental genetics in the fourth dimension: an illustration (by Kwang‐Hyun Cho himself) of the principle of dynamic network motifs in Drosophila development. Hitherto largely considered in terms of time‐invariant networks, drosophila development is viewed in the article by Man‐Sun Kim, Jeong‐Rae Kim, and Kwang‐Hyun Cho as the result of networks of gene interactions that change during the course of development. Using this paradigm, pivotal developmental events can be correlated with particular changes from one constellation of gene interactions (...)
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  • Dynamic network rewiring determines temporal regulatory functions in Drosophila_ _melanogaster development processes.Man-Sun Kim, Jeong-Rae Kim & Kwang-Hyun Cho - 2010 - Bioessays 32 (6):505-513.
    The identification of network motifs has been widely considered as a significant step towards uncovering the design principles of biomolecular regulatory networks. To date, time‐invariant networks have been considered. However, such approaches cannot be used to reveal time‐specific biological traits due to the dynamic nature of biological systems, and hence may not be applicable to development, where temporal regulation of gene expression is an indispensable characteristic. We propose a concept of a “temporal sequence of network motifs”, a sequence of network (...)
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