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  1. From Physics to Biology: Physicists in the Search for Systemic Biological Explanations.Leyla Mariane Joaquim, Olival Freire Jr & Charbel N. El-Hani - 2019 - European Journal for Philosophy of Science 9 (2):30.
    This paper offers a contribution to debates around integrative aspects of systems biology and engages with issues related to the circumstances under which physicists look at biological problems. We use oral history as one of the methodological tools to gather the empirical material, conducting interviews with physicists working in systems biology. The interviews were conducted at several institutions in Brazil, Germany, Israel and the U.S. Biological research has been increasingly dependent on computational methods, high-throughput technologies, and multidisciplinary skills. Quantitative scientists (...)
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  • Scientific Revolutions, Specialization and the Discovery of the Structure of DNA: Toward a New Picture of the Development of the Sciences.Politi Vincenzo - 2018 - Synthese 195 (5):2267-2293.
    In his late years, Thomas Kuhn became interested in the process of scientific specialization, which does not seem to possess the destructive element that is characteristic of scientific revolutions. It therefore makes sense to investigate whether and how Kuhn’s insights about specialization are consistent with, and actually fit, his model of scientific progress through revolutions. In this paper, I argue that the transition toward a new specialty corresponds to a revolutionary change for the group of scientists involved in such a (...)
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  • Biología de sistemas y biología sintética como tecnociencias emergentes.Karen Kastenhofer - 2016 - Isegoría 55:529.
    La biología de sistemas y la biología sintética pueden ser consideradas como ejemplos de tecnociencias emergentes. Están esencialmente marcadas por promesas de futuro y por visiones, por una cierta lógica y uso de términos, por determinadas formas de organización social, por la integración en un régimen específico de fomento e innovación, así como por una matriz característica de orientaciones para la praxis de investigación. Esta constitución específica de la biología de sistemas y de la biología sintética tiene, por su parte, (...)
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  • When Integration Fails: Prokaryote Phylogeny and the Tree of Life.Maureen A. O’Malley - 2013 - Studies in History and Philosophy of Science Part C 44 (4a):551-562.
    Much is being written these days about integration, its desirability and even its necessity when complex research problems are to be addressed. Seldom, however, do we hear much about the failure of such efforts. Because integration is an ongoing activity rather than a final achievement, and because today’s literature about integration consists mostly of manifesto statements rather than precise descriptions, an examination of unsuccessful integration could be illuminating to understand better how it works. This paper will examine the case of (...)
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  • The Many Lives of Experiments: Wilhelm Johannsen, Selection, Hybridization, and the Complex Relations of Genes and Characters.Robert Meunier - 2016 - History and Philosophy of the Life Sciences 38 (1):42-64.
  • Discipline-Building in Synthetic Biology.Bernadette Bensaude-Vincent - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):122-129.
    Despite the multidisciplinary dimension of the kinds of research conducted under the umbrella of synthetic biology, the US-based founders of this new research area adopted a disciplinary profile to shape its institutional identity. In so doing they took inspiration from two already established fields with very different disciplinary patterns. The analogy with synthetic chemistry suggested by the term ‘synthetic biology’ is not the only model. Information technology is clearly another source of inspiration. The purpose of the paper, with its focus (...)
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  • Pluralization through epistemic competition: scientific change in times of data-intensive biology.Fridolin Gross, Nina Kranke & Robert Meunier - 2019 - History and Philosophy of the Life Sciences 41 (1):1.
    We present two case studies from contemporary biology in which we observe conflicts between established and emerging approaches. The first case study discusses the relation between molecular biology and systems biology regarding the explanation of cellular processes, while the second deals with phylogenetic systematics and the challenge posed by recent network approaches to established ideas of evolutionary processes. We show that the emergence of new fields is in both cases driven by the development of high-throughput data generation technologies and the (...)
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  • Making Knowledge in Synthetic Biology: Design Meets Kludge.Maureen A. O’Malley - 2009 - Biological Theory 4 (4):378-389.
    Synthetic biology is an umbrella term that covers a range of aims, approaches, and techniques. They are all brought together by common practices of analogizing, synthesizing, mechanicizing, and kludging. With a focus on kludging as the connection point between biology, engineering, and evolution, I show how synthetic biology’s successes depend on custom-built kludges and a creative, “make-it-work” attitude to the construction of biological systems. Such practices do not fit neatly, however, into synthetic biology’s celebration of rational design. Nor do they (...)
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  • From Molecules to Systems: The Importance of Looking Both Ways.Alexander Powell & John Dupré - 2009 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 40 (1):54-64.
    Although molecular biology has meant different things at different times, the term is often associated with a tendency to view cellular causation as conforming to simple linear schemas in which macro-scale effects are specified by micro-scale structures. The early achievements of molecular biologists were important for the formation of such an outlook, one to which the discovery of recombinant DNA techniques, and a number of other findings, gave new life even after the complexity of genotype–phenotype
    relations had become apparent. Against this (...)
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  • Calculating Life? Duelling Discourses in Interdisciplinary Systems Biology.Jane Calvert & Joan H. Fujimura - 2011 - Studies in History and Philosophy of Science Part C 42 (2):155-163.
    A high profile context in which physics and biology meet today is in the new field of systems biology. Systems biology is a fascinating subject for sociological investigation because the demands of interdisciplinary collaboration have brought epistemological issues and debates front and centre in discussions amongst systems biologists in conference settings, in publications, and in laboratory coffee rooms. One could argue that systems biologists are conducting their own philosophy of science. This paper explores the epistemic aspirations of the field by (...)
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  • From the Genetic to the Computer Program: The Historicity of 'Data' and 'Computation' in the Investigations on the Nematode Worm C. Elegans (1963–1998). [REVIEW]Miguel García-Sancho - 2012 - Studies in History and Philosophy of Science Part C 43 (1):16-28.