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  1. A Tissue-Level Electromechanical Model of the Left Ventricle: Application to the Analysis of Intraventricular Pressure.Virginie Le Rolle, Guy Carrault, Pierre-Yves Richard, Philippe Pibarot & Louis-Gilles Durand - 2009 - Acta Biotheoretica 57 (4):457-478.
    The ventricular pressure profile is characteristic of the cardiac contraction progress and is useful to evaluate the cardiac performance. In this contribution, a tissue-level electromechanical model of the left ventricle is proposed, to assist the interpretation of left ventricular pressure waveforms. The left ventricle has been modeled as an ellipsoid composed of twelve mechano-hydraulic sub-systems. The asynchronous contraction of these twelve myocardial segments has been represented in order to reproduce a realistic pressure profiles. To take into account the different energy (...)
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  • Recursive Model Identification for the Evaluation of Baroreflex Sensitivity.Alfredo I. Hernández, Patrick Pladys, Nathalie Samson, Jean-Paul Praud, Alain Beuchée & Virginie Le Rolle - 2016 - Acta Biotheoretica 64 (4):469-478.
    A method for the recursive identification of physiological models of the cardiovascular baroreflex is proposed and applied to the time-varying analysis of vagal and sympathetic activities. The proposed method was evaluated with data from five newborn lambs, which were acquired during injection of vasodilator and vasoconstrictors and the results show a close match between experimental and simulated signals. The model-based estimation of vagal and sympathetic contributions were consistent with physiological knowledge and the obtained estimators of vagal and sympathetic activities were (...)
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