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  1. The Three Rs of Animal Research: What They Mean for the Institutional Animal Care and Use Committee and Why.Howard J. Curzer, Gad Perry, Mark C. Wallace & Dan Perry - 2016 - Science and Engineering Ethics 22 (2):549-565.
    The Institutional Animal Care and Use Committee is entrusted with assessing the ethics of proposed projects prior to approval of animal research. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, and Refinement. However, these principles are poorly defined. Although this provides the IACUC leeway in assessing a proposed project, it also affords little guidance. Our goal is to provide procedural and philosophical clarity (...)
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