Visual and Auditory Evoked Potentials in migraine: sensitivity and specificity as diagnostic tools
Anna
Ambrosini1*,
Aliaksei
Kisialiou2,
Livio
Finos3,
Judit
Afra4,
Gianluca
Coppola5,
Laura
Di Clemente6,
Ennio
Iezzi1,
Delphine
Magis7,
Peter
S.
Sandor8,
Tullia
Sasso D'Elia6,
Alessandro
Viganò6,
Michel
Fataki7,
Francesco
Pierelli6 and
Jean
Schoenen7
-
1
IRCCS Neuromed, Pozzilli (Isernia), Italy, Italy
-
2
University of Glasgow, United Kingdom
-
3
University of Padua, Italy
-
4
National Institute of Neurosurgery, Hungary
-
5
IRCCS Bietti Foundation, Italy
-
6
University "La Sapienza", Italy
-
7
University of Liège - CHR Citadelle, University Dept Neurology, Belgium
-
8
University of Zurich, Switzerland
Introduction: There are at present no reliable instrumental tests for the diagnosis of migraine. Many migraineurs are characterized interictally by a habituation deficit of visual evoked potentials (VEP) and/or increased intensity dependence of auditory evoked potentials (IDAP). In this retrospective study we tested the usefulness of VEP and IDAP as diagnostic tools in episodic migraineurs (EM).
Methods: We analyzed recordings from 360 healthy volunteers (HV) and 624 EM. VEP50 (5 blocks of 50 responses) were obtained in 77 HV and 231 EM, VEP100 (6 blocks of 100 responses) in 240 HV and 280 EM, IDAP in 86 HV and 328 EM. Some subjects underwent both VEP and IDAP tests. Thresholds were calculated by Receiver Operating Curve analysis, and used to calculate sensitivity, specificity and efficacy of each test.
Results: Sensitivity was 61.0% for VEP50, 61.4% for VEP100 and 45.7% for IDAP. Specificity was 77.9% for VEP50 and VEP100 and 87.2% for IDAP. Efficacy was 65.3% for VEP50, 69.0% for VEP100 and 54.3% for IDAP. In subjects who underwent both VEP and IDAP recordings, abnormality of at least one of them had a 83.4%, sensitivity, 66.7% specificity and 81.1% efficacy.
Conclusion: Taken alone, none of VEP or IDAP has sufficient diagnostic efficacy. However, when both tests are combined in the same patient, abnormality of at least one of them is highly predictive of migraine, suggesting that VEP and IDAP can contribute to the migraine diagnosis.
Keywords:
Migraine Disorders,
Evoked Potentials, Visual,
Evoked Potentials, Auditory,
Habituation study,
diagnostic test
Conference:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE, Ghent, Belgium, 4 Oct - 4 Oct, 2014.
Presentation Type:
Poster Presentation
Topic:
Clinical Neuroscience
Citation:
Ambrosini
A,
Kisialiou
A,
Finos
L,
Afra
J,
Coppola
G,
Di Clemente
L,
Iezzi
E,
Magis
D,
Sandor
PS,
Sasso D'Elia
T,
Viganò
A,
Fataki
M,
Pierelli
F and
Schoenen
J
(2014). Visual and Auditory Evoked Potentials in migraine: sensitivity and specificity as diagnostic tools.
Conference Abstract:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE.
doi: 10.3389/conf.fnhum.2014.214.00070
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Received:
02 Jul 2014;
Published Online:
16 Aug 2014.
*
Correspondence:
Dr. Anna Ambrosini, IRCCS Neuromed, Pozzilli (Isernia), Italy, Pozzilli, Isernia, Italy, anna.ambrosini@neuromed.it