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Schizophrenia is a disease of general connectivity more than a specifically “social brain” network

Published online by Cambridge University Press:  15 June 2005

Conrado Bosman ,
Enzo Brunetti  and
Francisco Aboitiz
Conrado Bosman*
Affiliation:
Departamento de Psiquiatría and Centro de Investigaciones Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta N 387, 2 Piso, Santiago 1, Chilewww.neuro.cl
Enzo Brunetti*
Affiliation:
Departamento de Psiquiatría and Centro de Investigaciones Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta N 387, 2 Piso, Santiago 1, Chilewww.neuro.cl
Francisco Aboitiz*
Affiliation:
Departamento de Psiquiatría and Centro de Investigaciones Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta N 387, 2 Piso, Santiago 1, Chilewww.neuro.cl
*
cbosman@med.puc.cl
ebrunett@med.puc.cl
faboitiz@puc.cl
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Abstract:

Dysfunctions of the neural circuits that implement social behavior are necessary but not a sufficient condition to develop schizophrenia. We propose that schizophrenia represents a disease of general connectivity that impairs not only the “social brain” networks, but also different neural circuits related with higher cognitive and perceptual functions. We discuss possible mechanisms and evolutionary considerations.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 27 , Issue 6 , December 2004 , pp. 856
Copyright
Copyright © Cambridge University Press 2004

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