Cingulate functional connectivity and emotional dysregulation in Major depressive Disorder
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1
UGent, Belgium
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2
VUB, Belgium
Albeit major depression disorder (MDD) is worldwide one of the most frequent diagnosed mental illnesses, at the brain level the phenomenon of treatment-resistant depression (TRD) still is not well understood. Besides pharmacotherapy, neurostimulation techniques such as repetitive Transcranial Magnetic Stimulation (rTMS) are currently under investigation to evaluate its use in TRD. Here, the subgenual anterior cingulate cortex (sgACC) has consistently been shown to be implicated as part of a deregulated neurocircuitry. Notwithstanding that resting state functional connectivity (rsFC) has been proposed as a new approach to investigate FC in deregulated brain areas no studies yet have focused on sgACC FC dysfunction in TRD. Our FC analyses confirm the importance of the sgACC in TRD deregulated networks during depressive episodes. Importantly, even in such refractory patients sgACC FC at baseline may indicate who eventually will respond or not to non-invasive brain stimulation techniques such as rTMS.
Acknowledgements
This research was supported by by the Ghent University Multidisciplinary Research Partnership “The integrative neuroscience of behavioral control”.
Keywords:
Major Depression Disorder,
rTMS,
functional connectivity,
subgenual anterior cingulate cortex,
dorsolateral prefrontal cortex (DLPFC)
Conference:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE, Ghent, Belgium, 4 Oct - 4 Oct, 2014.
Presentation Type:
Oral Presentation
Topic:
Clinical Neuroscience
Citation:
Baeken
C
(2014). Cingulate functional connectivity and emotional dysregulation in Major depressive Disorder.
Conference Abstract:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE.
doi: 10.3389/conf.fnhum.2014.214.00002
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Received:
26 Apr 2014;
Published Online:
10 May 2014.
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Correspondence:
Prof. Chris Baeken, UGent, 9000, Belgium, chris.baeken@ugent.be