Impact Of Genome-Wide Discovered Psychosis-Risk Gene ZNF804A On White Matter Integrity In Health And Psychosis
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1
Kings College London, Institute of Psychiatry, United Kingdom
Background: Schizophrenia and bipolar disorder have both been associated with reduced white matter integrity using fractional anisotropy (FA) under diffusion tensor imaging (DTI) as a proxy. Genetic susceptibility for both illnesses is higher due to the presence of allele A of SNP rs1344706 ZN4804A as detected by recent genome-wide studies. However, little is known on how this genetic factor impacts on the brain to increase risk for psychosis. The present study aimed to assess the impact of this risk variant on FA across patients with schizophrenia, patients with bipolar disorder and healthy controls. Methods: 230 individuals were genotyped for the SNP of interest and underwent DTI. Differences in FA were analysed using tract-based spatial statistics (TBSS) followed by ANOVA to assess underlying effects of genotype groups, diagnosis and their interaction. Results: Significant reductions in FA were associated with schizophrenia and bipolar disorder, and with the ZN4804A risk variant across all diagnostic groups. Conclusions: The present study provides further support for the involvement of rs1344706 ZNF804A in susceptibility for psychosis, and suggests this risk may be conferred through eliciting white matter microstructure abnormalities.
Keywords:
Cannabis,
Schizophrenia,
machine learning,
psychosis,
IQ,
genetic risk,
structural MRI,
childhood trauma,
Life stressors
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Cognition and Executive Processes
Citation:
Prata
D
(2015). Impact Of Genome-Wide Discovered Psychosis-Risk Gene ZNF804A On White Matter Integrity In Health And Psychosis.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00332
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Dr. Diana Prata, Kings College London, Institute of Psychiatry, London, United Kingdom, diana.prata@kcl.ac.uk