DCDC2 polymorphism is associated with cortical thickness in left supramarginal and angular gyri
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1
Karolinska Institute, Department of Neuroscience, Sweden
Background
Three genes, DYX1C1, DCDC2 and KIAA0319 have been repeatedly associated with dyslexia, neuronal migration and cilia function. Three polymorphisms within these genes, rs3743204 (DYX1C1), rs793842 (DCDC2) and rs6935076 (KIAA0319) have also been linked to normal variability of left temporo-parietal white matter volume connecting the middle temporal cortex to the angular and supramarginal gyri. Here, we assessed whether these polymorphisms are also related to the variability of cortical thickness in the parietal and temporal associated regions during childhood development.
Methods
Brain measures and behavioral scores were assessed using a longitudinal dataset of 76 randomly selected children and young adults (aged between 6 to 25 years) who were scanned up to 3 times, each 2 years apart. Cortical regions of interest were defined based on the fiber tracking of white matter regions previously associated with the three polymorphisms. Homologous regions in the right hemisphere were also included.
Results
Analyses confirmed the association of all polymorphisms to white matter volume connecting the inferior parietal and middle temporal lobes. Out of the 3 SNPs, rs793842 in DCDC2 was also significantly associated with cortical thickness of the left angular (p = 0.008) and supramarginal gyri (p = 2.68×—10-4). The cortex was significantly thicker for T-allele carriers, who also had lower white matter volume. Rs793842 was the only polymorphism that showed significant association with reading comprehension scores (p = 0.014), with lower reading scores identified amongst T-allele carriers.
Conclusion
These results show how normal variability in reading comprehension is related to genes, white matter volume and cortical thickness in the inferior parietal lobe. Possibly, the variability of gray and white matter structures could both be related to the role of DCDC2 in cilia function and neuronal migration.
Keywords:
cortical thickness,
white matter,
angular gyrus,
supramarginal gyrus,
reading ability,
Dyslexia genes
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Oral Presentation
Topic:
Language
Citation:
Darki
F and
Klingberg
T
(2015). DCDC2 polymorphism is associated with cortical thickness in left supramarginal and angular gyri.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00003
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Ms. Fahimeh Darki, Karolinska Institute, Department of Neuroscience, Stockholm, Sweden, fahimeh.darki@ki.se