For practical clinical purposes, as well as because of their deep philosophical implications, it becomes increasingly important to be aware of contemporary studies of the brain mechanisms that generate subjective experiences. Current research has progressed to the point where plausible theoretical proposals can be made about the neurophysiological and neurochemical processes which mediate perception and sustain subjective awareness. An adequate theory of consciousness must describe how information about the environment is encoded by the exogenous system, how memories are stored in the endogenous system and released appropriately for the present circumstances, how the exogenous and endogenous systems interact to produce perception, and explain how consciousness arises from that interaction. Evidence assembled from a variety of neuroscience areas, together with the invariant reversible electrophysiological changes observed with loss and return of consciousness in anesthesia as well as distinctive quantitative electroencephalographic profiles of various psychiatric disorders, provides an empirical foundation for this theory of consciousness. This evidence suggests the need for a paradigm shift to explain how the brain accomplishes the transformation from synchronous and distributed neuronal discharges to seamless global subjective awareness. This chapter undertakes to provide a detailed description and explanation of these complex processes by experimental evidence marshaled from a wide variety of sources.