Single word-related changes in cerebral oxy-Hb during discrimination task in schizophrenic patients: comparison with healthy subjects
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1
Kurume University, School of Medicine, Neuropsychiatry, Japan
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2
Kurume University, Cognitive and Molecular Research Institute of Brain Diseases, Japan
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3
Kurume University, Neuropsychiatry, Japan
Near-infrared spectroscopy (NIRS) is an optical imaging method that allows non-invasive in-vivo measurements of changes in oxygenated (oxy-Hb) and deoxygenated (deoxy-Hb) hemoglobin concentrations in brain. For the present study,we examine 30 patients with schizophrenia(age: 30.6±7.6) and age, sex- matched 30 healthy volunteers (age: 31.6±7.8) by means of multi-channel NIRS during performance of two kind of Shiritori task (standard and creative word). Two kinds of stimulus were appeared in front TV monitor. Single word (noun) for the target stimulus and and ‘a.i.u’for non-target stimulus with 10-12 s intervals. All subjects were asked to say '‘a.i.u’ as a non-target and do Shiritori as target stimulus. Averaged subtracted (target minus non-target) waveforms for the 20 target were measured, the changes in oxy-Hb were converted to numeric values every 100 ms. the approximated value of area change in oxy-Hb concentration during the performance of each task was also determined as the index [oxy-Hb]. The present data was obtained from the subjects produce more than 16 words. [oxy-Hb] were evaluated from four ROIs (religions of interest) as a frontal pole, middle prefrontal, association and temporal areas. [Oxy-Hb] in patients withschizophrenia were significantly smaller than those in healthy controls on frontal pole and middle prefrontal areas under standard and creative tasks. [oxy-Hb] on the left side were significantly larger than those on the right side in middle prefrontal area in healthy subjects. Single event-related [oxy-Hb] using discriminative Shiritori tasks are useful for evaluating psychophysiological indices.
Keywords:
Executive Function,
Psychophysiology,
Schizophrenia,
near-infrared spectroscopy,
Shiritori
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Cognition and Executive Processes
Citation:
Satou
M and
Morita
K
(2015). Single word-related changes in cerebral oxy-Hb during discrimination task in schizophrenic patients: comparison with healthy subjects.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00321
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Prof. Mamoru Satou, Kurume University, School of Medicine, Neuropsychiatry, Kurume, Japan, yshoji@med.kurume-u.ac.jp
Prof. Kiichiro Morita, Kurume University, School of Medicine, Neuropsychiatry, Kurume, Japan, Kiichiro@med.kurume-u.ac.jp