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An Ethical Problem Concerning Recent Therapeutic Research on Breast Cancer

Published online by Cambridge University Press:  25 March 2020

Don Marquis
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Abstract

The surgical treatment of breast cancer has changed in recent years. Analysis of the research that led to these changes yields apparently good arguments for all of the following: (1) The research yielded very great benefits for women. (2) There was no other way of obtaining these benefits. (3) This research violated the fundamental rights of the women who were research subjects. This sets a problem for ethics at many levels.

Type
Research Article
Information
Hypatia , Volume 4 , Issue 2: Special Issue: Feminist Ethics and Medicine , Summer 1989 , pp. 140 - 155
Copyright
Copyright © 1989 by Hypatia, Inc.

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References

Angell, Marcia. 1984. Patient preferences in randomized clinical trials. New England Journal of Medicine 310 (21): 1385–1387.CrossRefGoogle ScholarPubMed
Appelbaum, Paul S., Roth, Loren H., Lidz, Charles W., Benson, Paul, and Winslade, William. 1987. False hopes and best data: Consent to research and the therapeutic misconception. Hastings Center Report 17 (2): 20–24.CrossRefGoogle ScholarPubMed
Byar, David P. 1979. The necessity and justification of randomized clinical trials. In Controversies in cancer: Design of trials and treatment. Tagnon, Henri J. and Staquet, Maurice eds., New York: Masson.Google Scholar
Chalmers, Thomas. 1967. The ethics of randomization as a decision‐making technique and the problem of informed consent.Report of the 14th Conference of Cardiovascular Training Grant Program Directors. Bethesda, Maryland: National Heart Institute.Google Scholar
DeVita, Vincent T. Jr., Hellman, Samuel, and Rosenberg, Steven A. 1985. Cancer, principles and practice of oncology. Philadelphia: J. P. Lippencott Company.Google Scholar
Ellenberg, Susan. 1984. Randomization designs in comparative clinical trials. New England Journal of Medicine 310 (21): 1404–1408.CrossRefGoogle ScholarPubMed
Fisher, Bernard, Bauer, Madeline, Margolese, Richard, et al. 1985a. Five‐year results of a randomized clinical trial comparing total mastectomy and seg‐mental mastectomy with or without radiation in the treatment of breast cancer. New England Journal of Medicine 312 (11): 665–673.CrossRefGoogle Scholar
Fisher, Bernard, Redmond, Carol, Fisher, Edwin R., et al. 1985b. Ten‐year results of a randomized trial comparing radical mastectomy and total mastectomy with or without radiation. New England Journal of Medicine 312 (11): 674–681.CrossRefGoogle Scholar
Gifford, Fred. 1986. The conflict between randomized clinical trials and the therapeutic obligation. The Journal of Medicine and Philosophy 11 (4): 347–366.CrossRefGoogle ScholarPubMed
Katz, Jay. 1978. Informed consent in therapeutic relationships: Law and ethics. In Encyclopedia of bioethics. Reich, Warren T. ed., Glencoe: The Free Press.Google Scholar
Marquis, Don. 1986. An argument that all prerandomized clinical trials are unethical. The Journal of Medicine and Philosophy 11 (4): 367–384.CrossRefGoogle ScholarPubMed
Marquis, Don. 1983. Leaving therapy to chance: An impasse in the ethics of randomized clinical trials. Hastings Center Report 13 (4): 40–47.CrossRefGoogle Scholar
Robinson, Spotswood. 1972. Canterbury vs. Spence. U. S. Court of Appeals, District of Columbia Circuit. 464 Federal Reporter, 2nd Series, 772.Google Scholar
Sacks, Henry, Chalmers, Thomas, and Smith, Harry. 1982. Randomized versus historical controls for clinical trials. The American Journal of Medicine 72: 233–240.CrossRefGoogle ScholarPubMed
Taylor, Kathryn M., Margolese, Richard G., and Soskolne, Colin L. 1984 Physicians' reasons for not entering eligible patients in a randomized clinical trial of surgery for breast cancer. New England Journal of Medicine 310 (21): 1363–1367.CrossRefGoogle ScholarPubMed
Vaisrub, N. 1985. Manuscript review from a statistician's viewpoint. Journal of the American Medical Association 253 (2): 3145–3147.CrossRefGoogle Scholar
Zelen, Marvin. 1979. A new design for randomized trials. New England Journal of Medicine 300 (22): 1242–1245.CrossRefGoogle Scholar
Zelen, Marvin. 1977. Statistical options in clinical trials. Seminars in Oncobgy 4 (2): 441–446.Google ScholarPubMed