Direct electrophysiological registration of phonological and semantic perception in the human subthalamic nucleus
Miet
De Letter1, 2*,
Annelies
Aerts1,
Sarah
Vanhoutte1,
John
Van Borsel1, 3,
Robrecht
Raedt1,
Leen
De Taeye1,
Pieter
Van Mierlo1,
Paul
Boon1, 2,
Dirk
Van Roost1, 2 and
Patrick
Santens1, 2
-
1
Ghent University, Belgium
-
2
Ghent University Hospital, Belgium
-
3
Universidada Veiga de Almeida, Brazil
Background: The subcortico-cortical interaction in verb processing is under the influence of three circuits: the direct, indirect and hyperdirect pathway. Action verb and phonological processing is established by a process of mutual cortico-subcortical interaction within these three neural circuits. Damage of these systems have been related to semantic and phonologic dysfunction in pathologies such as aphasia after stroke and Parkinson's Disease.
Aims: Aside from the discussion about motor cortex involvement in action verb processing, this study determines if perception of action, non-action verbs, phonemes and words can be registered in the subthalamic nucleus (STN) and to what extent these semantic and phonological processes are sensitive for dopaminergic administration. Moreover we explore if the perception of action and non-action verbs as well as phonemes and words occurs at a different time frame in comparison with cortical regions.
Method: Direct eletrophysiological recording of the STN local field potential activity occurred one week after the implantations of the electrodes in seven patients with Parkinson's Disease. Semantic and phonologic related potentials were measured with and without dopaminergic administration. The results were compared with semantic and phonological cortical event-related activity, using the same language paradigms as in the current study.
Results: This study demonstrates that the STN is involved in the early stage (100 ms) of action and non-action verb detection, preceding cortical activity in the middle frontal gyrus at 100-140 ms and in the postrolandic area at 260-380 ms. After dopaminergic administration a second potential was elicited in the left STN at 200 ms. From phonological perspectives, the STN is involved in phonological perception, with shorter latencies of all the potentials in the STN than in the latencies obtained in the cerebral cortex in age-matched healthy controls.
Discussion: The involvement of the STN in phonological and semantic perception is especially important in the early processing of both modalities, which puts the STN undoubtedly in a position to modify semantic and phonological perception in a larger cortico-subcortical network.
References
Aerts, A., van Mierlo, P., Hartsuiker, R., Hallez, H., Santens, P., & De Letter, M. (2013). Neurophysiological investigation of phonological input: Aging effects and development of normative data. Brain and Language, 125(3), 253-263.
Vanhoutte, S., Strobbe, G., Van Mierlo, P., Cosyns, M., Corthals, P., De Letter, M., Van Borsel, J., & Santens, P. Early and late lexico-semantic modulation of motor related areas during action/non-action verb processing in fluent and stuttering speakers (submitted).
Keywords:
Subthalamic Nucleus,
Language,
phonology,
semantics,
Electrophysiology,
Deep Brain Stimulation
Conference:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE, Ghent, Belgium, 4 Oct - 4 Oct, 2014.
Presentation Type:
Poster Presentation
Topic:
Clinical Neuroscience
Citation:
De Letter
M,
Aerts
A,
Vanhoutte
S,
Van Borsel
J,
Raedt
R,
De Taeye
L,
Van Mierlo
P,
Boon
P,
Van Roost
D and
Santens
P
(2014). Direct electrophysiological registration of phonological and semantic perception in the human subthalamic nucleus.
Conference Abstract:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE.
doi: 10.3389/conf.fnhum.2014.214.00023
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Received:
26 Jun 2014;
Published Online:
30 Jun 2014.
*
Correspondence:
Dr. Miet De Letter, Ghent University, Ghent, Belgium, miet.deletter@ugent.be