Abstract
After 5 weeks of voluntary wheel running, C57BL/6J mice were significantly resistant to the sleep-inducing effects of ethanol. Sixty-four mice, 32 males and 32 females, were assigned to wheel (free access to a running wheel in the home cage) or no-wheel conditions. At the end of the training period, the animals were removed from the exercise cages and tested for sensitivity to ethanol (3.16 g/kg, 20% w/v), assessed by loss-of-righting reflex (LORR). Exercised animals showed significantly longer latency to LORR (fall time) and shorter duration of LORR (sleep time). Exercise caused a significant decrease in body weight in male, but not female, mice. The present results suggest that exercise training may be effective in reducing ethanol-induced sleep.
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Ardies, C. M., Morris, G. S., Erickson, C. K., & Farrar, R. P. (1989). Both acute and chronic exercise enhance in vivo ethanol clearance in rats. Journal of Applied Physiology, 66, 555–560.
Baak, van M. A. (1990). Influence of exercise on the pharmacokinetics of drugs. Clinical Pharmacokinetics, 19, 32–43.
Baker, R. C., Smolen, A., Smolen, T. N., & Deitrich, R. A. (1987). Relationship between acute ethanol-related responses in Long-Sleep and Short-Sleep mice. Alcoholism: Clinical & Experimental Research, 11, 574–578.
Faulkner, T. P., Cantleberry, S. B., Watts, V. J., & Hussain, A. S. (1990). Comparative pharmacokinetics of ethanol in inbred strains of mice using doses based on total body water. Alcoholism: Clinical & Experimental Research, 14, 82–86.
Frenkl, R., Gyore, A., & Szeberenyi, S. (1980). The effect of muscular exercise on the microsomal enzyme system of the rat liver. European Journal of Applied Physiology, 44, 135–140.
Goodrick, C. L. (1978). Effect of voluntary wheel exercise on food intake, water intake, and body weight for C57BL/6J mice and mutations which differ in maximal body weight. Physiology & Behavior, 21, 345–351.
Romm, E., & Collins, A. C. (1987). Body temperature influences on ethanol elimination rate. Alcohol, 4, 189–198.
Samorajski, T., Delaney, C., Durham, L., Ordy, J. M., Johnson, J. A., & Dunlap, W. P. (1985). Effect of exercise on longevity, body weight, locomotor performance, and passive-avoidance memory of C57BL/6J mice. Neurobiology of Aging, 6, 17–24.
Schurch, P. M., Radimsky, J., Iffland, R., & Hollmann, W. (1982). The influence of moderate prolonged exercise and a low carbohydrate diet on ethanol elimination and on metabolism. European Journal of Applied Physiology, 48, 407–414.
Smolen, A., & Smolen, T. N. (1987). Demonstration of a threshold concentration for ethanol at the time of regaining the righting response in Long-Sleep and Short-Sleep mice. Alcohol & Drug Research, 7, 279–283.
Smolen, A., Smolen, T. N., & Kamp, van de J. L. (1987). Sensitivity of inbred and selectively bred mice to ethanol. Alcohol, 4, 57–62.
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Mollenauer, S., Bryson, R. & Phillips, C. Voluntary exercise: Effects on ethanol-induced sleep in the C57BL/6J mouse. Bull. Psychon. Soc. 29, 217–219 (1991). https://doi.org/10.3758/BF03335239
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DOI: https://doi.org/10.3758/BF03335239