Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Abstract 


Recent research governance documents say that the body of research evidence must reflect population diversity. The response to this needs to be more sophisticated than simply ensuring minorities are present in samples. For quantitative research looking primarily at treatment effects of drugs and devices four suggestions are made. First, identify where the representation of minorities in samples matters-for example, where ethnicity may cause different treatment effects. Second, where the representation of a particular group matters then subgroup analysis of the results will usually be necessary. Third, ensuring representation and subgroup analysis will have costs; deciding on whether such representation is worthwhile will involve cost benefit analysis. Fourth, the representation of minorities should not be seen as mainly a locality issue. For qualitative research it is argued that the representation of diversity is often important. Given the small samples of many qualitative projects, however, the best way to ensure representation occurs is to allow a proliferation of such research, not to stipulate such representation in samples.

Free full text 


Logo of jmedethLink to Publisher's site
J Med Ethics. 2004 Apr; 30(2): 185–189.
PMCID: PMC1733844
PMID: 15082815

Should research samples reflect the diversity of the population?

Abstract

Recent research governance documents say that the body of research evidence must reflect population diversity. The response to this needs to be more sophisticated than simply ensuring minorities are present in samples.

For quantitative research looking primarily at treatment effects of drugs and devices four suggestions are made. First, identify where the representation of minorities in samples matters—for example, where ethnicity may cause different treatment effects. Second, where the representation of a particular group matters then subgroup analysis of the results will usually be necessary. Third, ensuring representation and subgroup analysis will have costs; deciding on whether such representation is worthwhile will involve cost benefit analysis. Fourth, the representation of minorities should not be seen as mainly a locality issue.

For qualitative research it is argued that the representation of diversity is often important. Given the small samples of many qualitative projects, however, the best way to ensure representation occurs is to allow a proliferation of such research, not to stipulate such representation in samples.

Full Text

The Full Text of this article is available as a PDF (168K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Corbie-Smith Giselle, Thomas Stephen B, St George Diane Marie M. Distrust, race, and research. Arch Intern Med. 2002 Nov 25;162(21):2458–2463. [Abstract] [Google Scholar]
  • Flaskerud JH, Nyamathi AM. Attaining gender and ethnic diversity in health intervention research: cultural responsiveness versus resource provision. ANS Adv Nurs Sci. 2000 Jun;22(4):1–15. [Abstract] [Google Scholar]
  • Mason Su, Hussain-Gambles Mahvash, Leese Brenda, Atkin Karl, Brown Julia. Representation of South Asian people in randomised clinical trials: analysis of trials' data. BMJ. 2003 Jun 7;326(7401):1244–1245. [Europe PMC free article] [Abstract] [Google Scholar]
  • Bartlett C, Davey P, Dieppe P, Doyal L, Ebrahim S, Egger M. Women, older persons, and ethnic minorities: factors associated with their inclusion in randomised trials of statins 1990 to 2001. Heart. 2003 Mar;89(3):327–328. [Europe PMC free article] [Abstract] [Google Scholar]
  • De Amici D, Klersy C, Ramajoli F, Brustia L. More about the Hawthorne effect. Anesth Analg. 2000 Oct;91(4):1043–1043. [Abstract] [Google Scholar]
  • Burroughs Valentine J, Maxey Randall W, Levy Richard A. Racial and ethnic differences in response to medicines: towards individualized pharmaceutical treatment. J Natl Med Assoc. 2002 Oct;94(10 Suppl):1–26. [Abstract] [Google Scholar]
  • Carr J, Ives J, Kelly L, Lambkin R, Oxford J, Mendel D, Tai L, Roberts N. Influenza virus carrying neuraminidase with reduced sensitivity to oseltamivir carboxylate has altered properties in vitro and is compromised for infectivity and replicative ability in vivo. Antiviral Res. 2002 May;54(2):79–88. [Abstract] [Google Scholar]
  • Johnson JA. Influence of race or ethnicity on pharmacokinetics of drugs. J Pharm Sci. 1997 Dec;86(12):1328–1333. [Abstract] [Google Scholar]
  • Witzig R. The medicalization of race: scientific legitimization of a flawed social construct. Ann Intern Med. 1996 Oct 15;125(8):675–679. [Abstract] [Google Scholar]
  • Zuccalà G, Onder G, Carbonin P, Bernabei R. Adverse drug reactions in the elderly: need for dedicated databases. Arch Intern Med. 2000 Jun 12;160(11):1700–1701. [Abstract] [Google Scholar]
  • Platzer H, James T. Methodological issues conducting sensitive research on lesbian and gay men's experience of nursing care. J Adv Nurs. 1997 Mar;25(3):626–633. [Abstract] [Google Scholar]
  • Free Caroline, Lee Raymond M, Ogden Jane. Young women's accounts of factors influencing their use and non-use of emergency contraception: in-depth interview study. BMJ. 2002 Dec 14;325(7377):1393–1393. [Europe PMC free article] [Abstract] [Google Scholar]
  • Hauser JM, Kleefield SF, Brennan TA, Fischbach RL. Minority populations and advance directives: insights from a focus group methodology. Camb Q Healthc Ethics. 1997 Winter;6(1):58–71. [Abstract] [Google Scholar]
  • Chevannes Mel. Issues in educating health professionals to meet the diverse needs of patients and other service users from ethnic minority groups. J Adv Nurs. 2002 Aug;39(3):290–298. [Abstract] [Google Scholar]
  • Ashcroft RE, Chadwick DW, Clark SR, Edwards RH, Frith L, Hutton JL. Implications of socio-cultural contexts for the ethics of clinical trials. Health Technol Assess. 1997;1(9):i–65. [Abstract] [Google Scholar]
  • Labonte Ronald, Spiegel Jerry. Setting global health research priorities. BMJ. 2003 Apr 5;326(7392):722–723. [Europe PMC free article] [Abstract] [Google Scholar]

Articles from Journal of Medical Ethics are provided here courtesy of BMJ Publishing Group

Citations & impact 


Impact metrics

Jump to Citations

Citations of article over time

Article citations


Go to all (40) article citations