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The Curious Case of the Spanish Flu

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Abstract

It is often claimed that the exceptional severity of the Spanish flu, one of the most deadly events in recorded human history, is an unsolved mystery. However, even detailed aspects such as its W-shaped mortality curve are well explained by Paul Ewald’s theory of the evolution of virulence. Understanding the causes of the Spanish flu will help to prevent future epidemics.

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Fig. 1

(Reprinted with permission from Emerging Infectious Diseases, published by Centers for Disease Control and Prevention; Taubenberger and Morens 2006, p. 19)

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References

  • Barrett R, Brown PJ (2008) Stigma in the time of influenza: social and institutional responses to pandemic emergencies. J Infect Dis 197:34–37

    Article  Google Scholar 

  • Byerly CR (2005) Fever of war. The influenza epidemic in the U.S. army. New York University Press, New York

    Google Scholar 

  • Chowell G, Ammon CE, Hengartner NW, Hyman JM (2006) Estimation of the reproductive number of the Spanish flu epidemic in Geneva, Switzerland. Vaccine 24:6747–6750

    Article  Google Scholar 

  • Craig R (2017) The mystery of a 1918 veteran and the flu pandemic. In: The conversation. https://theconversation.com/the-mystery-of-a-1918-veteran-and-the-flu-pandemic-86292. Accessed 14 Sept 2018

  • Ewald PW (1991) Transmission modes and the evolution of virulence. With special reference to cholera, influenza, and AIDS. Hum Nat 2(1):1–30

    Article  Google Scholar 

  • Ewald PW (1993) The evolution of virulence. Sci Am 268(4):86–93

    Article  Google Scholar 

  • Ewald PW (2011) Evolution of virulence, environmental change, and the threat posed by emerging and chronic diseases. Ecol Res 26:1017–1026

    Article  Google Scholar 

  • Hammond JAR, Rolland W, Shore THG (1917) Purulent bronchitis: a study of cases occurring amongst the British troops at a base in France. Lancet 2:41–45

    Article  Google Scholar 

  • Humphries MO (2013) Paths of infection: the First World War and the origins of the 1918 influenza pandemic. War Hist 21(1):55–81

    Article  Google Scholar 

  • Jefferson T, Ferroni E (2009) Spanish flu through the BMJ’s eyes. Br Med J 339(7735):1397–1399

    Google Scholar 

  • Morens DM, Fauci AS (2007) The 1918 influenza pandemic: insights for the 21st century. J Infect Dis 195:1018–1028

    Article  Google Scholar 

  • Morens DM, Taubenberger JK, Fauci AS (2008) Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis 198:1–9

    Article  Google Scholar 

  • Noymer A, Garenne M (2000) The 1918 influenza epidemic’s effects on sex differentials in mortality in the United States. Popul Dev Rev 26(3):565–581

    Article  Google Scholar 

  • Oxford JS, Sefton A, Jackson R et al (2002) World War I may have allowed the emergence of “Spanish” influenza. Lancet Infect Dis 2:111–114

    Article  Google Scholar 

  • Robertson JD (1918) “Spanish Influenza"--"The Flu”. Public Health J 9(10):482–485

    Google Scholar 

  • Shanks GD (2016) No evidence of 1918 influenza pandemic origin in Chinese laborers/soldiers in France. J Chin Med Assoc 79:46–48

    Article  Google Scholar 

  • Shortridge KF (1999) The 1918 ‘Spanish’ flu: pearls from swine? Nat Med 5(4):384–385

    Article  Google Scholar 

  • Tansey T (2017) A viral world war. Nature 546:207–208

    Article  Google Scholar 

  • Taubenberger JK, Morens DM (2006) 1918 influenza: the mother of all pandemics. Emerg Infect Dis 12(1):15–22. https://doi.org/10.3201/eid1201.050979

    Article  Google Scholar 

  • Wilson N, Oliver J, Rice G et al (2014) Age-specific mortality during the 1918–19 influenza pandemic and possible relationship to the 1889–92 influenza pandemic. J Infect Dis 210:993–995

    Article  Google Scholar 

Download references

Acknowledgements

I thank two reviewers for their comments, and once again, Hamilton McMillan was a great help with the text.

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Correspondence to Frans Roes.

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Roes, F. The Curious Case of the Spanish Flu. Biol Theory 13, 243–245 (2018). https://doi.org/10.1007/s13752-018-0307-9

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