Functional brain correlates of psychiatric function in Huntington's disease: The Image-HD study
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1
Monash University, School of Psychology and Psychiatry, Australia
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2
Monash Biomedical Imaging, Australia
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3
Monash Medical Centre, Department of Neurology, Australia
Background: The purpose of this study was to investigate the relationship between psychiatric symptoms and functional brain activity (BOLD) during working memory performance in Huntington's disease (HD).
Methods: The sample comprised of pre-manifest HD far from onset (pre-HD far, n=17), pre-manifest HD close to onset (pre-HD close, n=18), symptomatic HD (symp-HD, n=23) and controls (n=32). Functional magnetic resonance imaging (fMRI) was used to investigate BOLD activation during a N-BACK (1-BACK & 2-BACK) working memory task. Brain regions of interest included the bilateral dorsolateral prefrontal cortex (DLPFC), bilateral caudate, bilateral superior parietal lobule (SPL), and anterior cingulate cortex (ACC).
Results: Correlations were performed between BOLD activation in each brain region and scores on a battery of neuropsychiatric inventories (BDI, HADS-A & HADS-D, SCOPI, & FRSBE), while controlling for age, gender, and accuracy on the working memory task. For 1-BACK, significant negative correlations were found in the pre-HD close to onset group between neuropsychiatric disturbance (SCOPI and the SCOPI "checking" subscale) and BOLD activation in the right DLPFC. For 2-BACK, negative correlations between neuropsychiatric dysfunction (SCOPI and the SCOPI "checking" and "cleaning" subscales) and BOLD activation in the pre-HD close to onset group were found in the right DLPFC, right caudate, and ACC. No significant correlations were found in the pre-HD far to onset or symp-HD groups.
Discussion: These findings suggest a relationship between brain function and psychiatric disturbance in pre-HD individuals that becomes more pronounced with approach to disease onset and during higher working memory loads.
Keywords:
Huntington Disease,
Psychiatry,
dorsolateral prefrontal cortex,
fMRI BOLD,
nback
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Cognition and Executive Processes
Citation:
Driscoll
S,
Poudel
G,
Stout
J,
Dominguez
J,
Churchyard
A,
Chua
P and
Egan
G
(2015). Functional brain correlates of psychiatric function in Huntington's disease: The Image-HD study.
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00158
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Ms. Shannon Driscoll, Monash University, School of Psychology and Psychiatry, Clayton, Australia, Shannon.Driscoll@monash.edu