Differences in contact heat-evoked potentials (CHEPs) between healthy subjects and patients with episodic or chronic migraine
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1
Headache Research Unit, University Department of Neurology, Belgium
Introduction
Habituation and 1st block amplitude of sensory evoked potentials are commonly reduced in episodic migraine between attacks, whereas in chronic migraine 1st block amplitude is increased and habituation tends to normalize like during an attack. By contrast, laser-evoked nociceptive potentials lack habituation during attacks and in medication overuse headache. The aim of our study was to compare Contact Heat-Evoked Potentials (CHEPs) in healthy subjects (HS), episodic migraine without aura (EM) and chronic migraine (CM).
Methods
Ninety subjects participated in the study: 53 HS, 31 EM and 6 CM. CHEPs were obtained using 53°C stimuli on the forehead and the wrist. Twenty responses were averaged and partitioned in 5 blocks of 4 responses. We measured P1, N2 and P2 latencies and P1-N2 and N2-P2 amplitudes. The linear regression slope over the 5 successive blocks defined habituation. Pain was rated using a visual analog scale (VAS). Data were analyzed with ANOVA and post-hoc Scheffe’s test.
Results
There was no significant difference in CHEPs latency, amplitude or habituation between HS and EM either in the forehead or at the wrist. By contrast, in CM patients P1-N2 amplitude after forehead stimulation was increased (p=0.04) and habituation more pronounced (p=0.04). Both at forehead and wrist VAS pain ratings were significantly higher in CM than in HS (p=0.02) or EM (p=0.01).
Conclusion
We found no difference between HS and interictal EM for thermonociceptive evoked potentials. Contrasting with these findings, CM patients display increased CHEPs amplitude, CHEPs habituation and pain perception. Such a pattern is similar to that found in these patients with visual evoked responses and may be due to central sensitisation and increased thalamo-cortical drive.
Acknowledgements
This work was supported by the research convention 3.4.650.09 of the National Fund for Scientific Research-Belgium to JS.
References
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Keywords:
Migraine Disorders,
chronic migraine,
Pain,
contact heat,
episodic migraine,
trigeminal path
Conference:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE, Ghent, Belgium, 4 Oct - 4 Oct, 2014.
Presentation Type:
Oral Presentation
Topic:
Clinical Neuroscience
Citation:
Sava
S,
Baschi
R,
Sasso D'Elia
T,
La Salvia
V,
De Pasqua
V,
Magis
D and
Schoenen
J
(2014). Differences in contact heat-evoked potentials (CHEPs) between healthy subjects and patients with episodic or chronic migraine.
Conference Abstract:
Belgian Brain Council 2014
MODULATING THE BRAIN: FACTS, FICTION, FUTURE.
doi: 10.3389/conf.fnhum.2014.214.00077
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Received:
09 Jul 2014;
Published Online:
02 Sep 2014.
*
Correspondence:
Mrs. Simona Liliana Sava, Headache Research Unit, University Department of Neurology, Liège, 4000, Belgium, simonaliliana.sava@gmail.com