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Mechanistic Explanation of Biological Processes

Published online by Cambridge University Press:  01 January 2022

Abstract

Biological processes are often explained by identifying the underlying mechanisms that generate a phenomenon of interest. I characterize a basic account of mechanistic explanation and then present three challenges to this account, illustrated with examples from molecular biology. The basic mechanistic account (1) is insufficient for explaining nonsequential and nonlinear dynamic processes, (2) is insufficient for explaining the inherently stochastic nature of many biological mechanisms, and (3) fails to give a proper framework for analyzing organization. I suggest that biological processes are best approached as a multidimensional gradient—with some processes being paradigmatic cases of mechanisms and some being marginal cases.

Type
Biology
Copyright
Copyright © The Philosophy of Science Association

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Footnotes

I would like to thank Peter Godfrey-Smith, Massimo Pigliucci, and Arnon Levy for helpful comments and stimulating discussions. I am especially grateful to Shawn Simpson for providing illustrations. Thanks also to the many participants at the 2014 PSA who offered helpful feedback.

References

Andersen, Holly. 2012. “The Case for Regularity in Mechanistic Causal Explanation.” Synthese 189:415–32.CrossRefGoogle Scholar
Bechtel, William. 2011. “Mechanism and Biological Explanation.” Philosophy of Science 78 (4): 533–57.CrossRefGoogle Scholar
Bechtel, William 2012. “Understanding Endogenously Active Mechanisms: A Scientific and Philosophical Challenge.” European Journal for Philosophy of Science 2 (2): 233–48.CrossRefGoogle Scholar
Bechtel, William, and Abrahamsen, Adele. 2005. “Explanation: A Mechanist Alternative.” Studies in History and Philosophy of the Biological and Biomedical Sciences 36:421–41.CrossRefGoogle ScholarPubMed
Bechtel, William, and Abrahamsen, Adele 2013. “Thinking Dynamically about Biological Mechanisms: Networks of Coupled Oscillators.” Foundations of Science 18:707–23.CrossRefGoogle Scholar
Bechtel, William, and Richardson, Robert C.. 1993/1993. Discovering Complexity: Decomposition and Localization as Strategies in Scientific Research. Repr. Cambridge, MA: MIT Press.Google Scholar
Berridge, Michael J., Bootman, Martin D., and Roderick, H. Llewelyn. 2003. “Calcium Signalling: Dynamics, Homeostasis and Remodelling.” Nature Reviews: Molecular Cell Biology 4:517–29.CrossRefGoogle ScholarPubMed
Glennan, Stuart. 1996. “Mechanisms and the Nature of Causation.” Erkenntnis 44:5071.CrossRefGoogle Scholar
Glennan, Stuart 2002. “Rethinking Mechanistic Explanation.” Philosophy of Science 69 (Proceedings): S342S353.CrossRefGoogle Scholar
Godfrey-Smith, Peter. 2009. Darwinian Populations and Natural Selection. Oxford: Oxford University Press.CrossRefGoogle Scholar
Levy, Arnon. 2013. “Three Kinds of New Mechanism.” Biology and Philosophy 28:99114.CrossRefGoogle Scholar
Levy, Arnon 2014. “Machine-Likeness and Explanation by Decomposition.” Philosopher’s Imprint 14 (6).Google Scholar
Levy, Arnon, and Bechtel, William. 2013. “Abstraction and the Organization of Mechanisms.” Philosophy of Science 80 (2): 241–61.CrossRefGoogle Scholar
Machamer, Peter, Darden, Lindley, and Craver, Carl F.. 2000. “Thinking about Mechanisms.” Philosophy of Science 67:125.CrossRefGoogle Scholar
Moore, Peter B. 2012. “How Should We Think about the Ribosome?Annual Review of Biophysics 41:119.CrossRefGoogle ScholarPubMed
Nicholson, Daniel J. 2012. “The Concept of Mechanism in Biology.” Studies in History and Philosophy of Biological and Biomedical Sciences 43:152–63.CrossRefGoogle ScholarPubMed
Wimsatt, William C. 1986. “Forms of Aggregativity.” In Human Nature and Natural Knowledge, ed. Donagan, Alan, Perovich, Anthony N., and Wedin, Michael V., 259–93. Dordrecht: Reidel.Google Scholar
Woodward, James. 2003. Making Things Happen: A Theory of Causal Explanation. Oxford: Oxford University Press.Google Scholar