Mismatch Field Provides a Biological Link Between High Autistic and Schizotypal Tendencies.
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1
Swinburne University of Technology, Australia
The autism and schizophrenia spectra are well established as characteristic phenotypes existing on a continuum from pathology to personality traits. As evidence broadens, research shows striking interpersonal and social cognitive dysfunction similarities between the spectra, highlighting the need for biological markers. Mismatch Negativity/Field (MMN/F) quantifies pre-attentive processing, with temporal change detection deficits indexing various social, cognitive and functional abnormalities. We investigate the relationship between duration MMF and specific autistic and schizotypal tendency phenotypes.
From a pool of 176 respondents to an online Autism Spectrum Quotient (AQ) and Schizotypal Personality Questionnaire (SPQ), aged 18 to 40, 28 participants: nine Control (m/f=5/4), seven High AQ (HA) (m/f=4/3), five High SPQ (HS)(m/f=5/0), and six High AQ/SPQ (HAS)) (m/f=4/2) were recruited for the MEG MMF scan. Correlations between MMF (long and short duration), and AQ and SPQ (total and subscale scores) were obtained. Furthermore, subsequent correlations were obtained between MMF and the two component scores revealed in the AQ and SPQ subscale Principal Components Analysis (PCA).
Over the right auditory cortex, the long deviant MMF was significantly correlated with AQ total (-.51) and subscales Social Skills (-.42), Communication (-.42), Attention to Detail (-.38) and Imagination (-.47), SPQ total (-.51) and subscales Ideas of Reference (-.5), Suspiciousness (-.39), Social Anxiety (-.58) and No Close Friends (-.47), and PCA Component 1 (Interpersonal-Communication) (-.48) and Component 2 (Perceptual-Disorganisation) (-.42). The short duration MMF was significantly correlated with Communication (-.41) and Imagination (-.48).
We conclude that temporal change detection abnormalities, particularly increased length, index social cognitive dysfunction, and thus highlight a potential biomarker for the phenotypic link between autism and schizophrenia spectrum disorders.
Keywords:
MEG,
social cognition,
social perception,
autistic tendency,
Mismatch Field,
Schizotypal Tendency
Conference:
XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014.
Presentation Type:
Poster
Topic:
Emotional and Social Processes
Citation:
Ford
T and
Crewther
D
(2015). Mismatch Field Provides a Biological Link Between High Autistic and Schizotypal Tendencies..
Conference Abstract:
XII International Conference on Cognitive Neuroscience (ICON-XII).
doi: 10.3389/conf.fnhum.2015.217.00175
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Received:
19 Feb 2015;
Published Online:
24 Apr 2015.
*
Correspondence:
Miss. Talitha Ford, Swinburne University of Technology, Melbourne, Australia, talitha.ford@deakin.edu.au
Prof. David Crewther, Swinburne University of Technology, Melbourne, Australia, dcrewther@swin.edu.au