Hostname: page-component-848d4c4894-x5gtn Total loading time: 0 Render date: 2024-05-11T14:05:23.286Z Has data issue: false hasContentIssue false
  • English
  • Français

Reunifying autism and early-onset schizophrenia in terms of social communication disorders

Published online by Cambridge University Press:  26 June 2008

Sylvie Tordjman
Sylvie Tordjman
Affiliation:
Department of Child and Adolescent Psychiatry, University of Rennes 1 and Laboratoire de Psychologie de la Perception, CNRS FRE 2929, University of Paris 5, France. s.tordjman@ch-guillaumeregnier.fr
Get access Rights & Permissions [Opens in a new window]

Abstract

Autism and early-onset schizophrenia share common dimensions of social communication deficits. The possible role of common genetic factors has to be seriously considered, such as the serotonin transporter gene that influences the severity of social communication impairments (negative symptoms) and hallucinations (positive symptoms). Autism and the negative syndrome of schizophrenia might be at one extreme of a continuum, and paranoid schizophrenia (positive symptoms) at the other extreme.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 31 , Issue 3 , June 2008 , pp. 278 - 279
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alaghband-Rad, J., McKenna, K. & Gordon, C. T. (1995) Childhood onset schizophrenia: The severity of premorbid course. Journal of the American Academy of Child and Adolescent Psychiatry 34:1275–83.Google ScholarPubMed
Asarnow, J. R., Tompson, M. C. & Goldstein, M. J. (1994) Childhood-onset schizophrenia: A follow-up study. Schizophrenia Bulletin 20(4):599–617.CrossRefGoogle Scholar
Bailer, J., Brauer, W. & Rey, E. R. (1996) Premorbid adjustment as predictor of outcome in schizophrenia: Results of a prospective study. Acta Psychiatrica Scandinavica 93(55):368–77.CrossRefGoogle ScholarPubMed
Baum, K. M. & Walker, E. F. (1995) Childhood behavioral precursors of adult symptom dimensions in schizophrenia. Schizophrenia Research 16:111–20.CrossRefGoogle ScholarPubMed
Bender, L. & Faetra, G. (1972) The relationship between childhood and adult schizophrenia. In: Genetic factors in schizophrenia, ed. Kaplan, A. R., pp. 28–64. Charles C. Thomas.Google Scholar
Brune, C. W., Kim, S. J., Salt, J., Leventhal, B. L., Lord, C. & Cook, E. H. (2006) 5-HTTLPR genotype-specific phenotype in children and adolescents with autism. American Journal of Psychiatry 163:2148–56.CrossRefGoogle ScholarPubMed
Cantor, S., Evans, J., Pearce, J. & Pezzot-Pearce, T. (1982) Childhood schizophrenia: Present but not accounted for. American Journal of Psychiatry 139:758–62.Google Scholar
Carpenter, W. T., Heinrichs, D. W. & Wagman, A. M. (1988) Deficit and nondeficit forms of schizophrenia: The concept. American Journal of Psychiatry 145:578–83.Google ScholarPubMed
Golimbet, V. E., Alfimova, M. V., Shcherbatikh, T., Kaleda, V. G., Abramova, L. I. & Rogaev, E. I. (2003) Serotonin transporter gene polymorphism and schizoid personality traits in the patients with psychosis and psychiatrically well subjects. World Journal of Biological Psychiatry 4(1):25–29.CrossRefGoogle Scholar
Guieu, R., Samuelian, J. C. & Coulouvrat, H. (1994) Objective evaluation of pain perception in patients with schizophrenia. British Journal of Psychiatry 164:253–55.CrossRefGoogle ScholarPubMed
Jacobson, J. W. & Ackerman, L. J. (1990) Differences in adaptive functioning among people with autism or mental retardation. Journal of Autism and Developmental Disorders 20:205–19.CrossRefGoogle ScholarPubMed
Jansen, L. M. C. (1998) Blunted cortisol response to a psychosocial stressor in schizophrenia. Schizophrenia Research 33:87–94.CrossRefGoogle ScholarPubMed
Jansen, L. M. C., Gispen-De Wied, C. C., Van der Gaag, R. J., Ten Hove, F., Willemsenswinkels, S. W. M., Harteveld, E. & van Engeland, H. (2000) Unresponsiveness to psychosocial stress in a subgroup of autistic-like children, multiple complex developmental disorder. Psychoneuroendocrinology 25:753–64.CrossRefGoogle Scholar
Kanner, L. (1943) Autistic disturbances of affective contact. Nervous Child 32:217–53.Google Scholar
Konstantareas, M. M. & Hewitt, T. (2001) Autistic disorder and schizophrenia: Diagnostic overlaps. Journal of Autism and Developmental Disorders 31(1):19–28.CrossRefGoogle ScholarPubMed
Krauss, H., Marwinski, K., Schulze, T., Mueller, D. J., Held, T., Rietschel, M., Maier, W. & Freyberger, H. J. (2000) Reliability and validity of the German version of the Premorbid Adjustment Scale (PAS). Nervenarzt 71(3):188–94.CrossRefGoogle ScholarPubMed
Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D, Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H. & Murphy, D. L. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274(5292):1527–31.CrossRefGoogle ScholarPubMed
Malhotra, A. K., Goldman, D., Mazzanti, C., Clifton, A., Breier, A. & Pickard, D. (1998) A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics. Molecular Psychiatry 3:328–32.CrossRefGoogle ScholarPubMed
Mueser, K. T., Bellack, A. S., Douglas, M. S. & Morrison, R. L. (1991) Prevalence and stability of social skill deficits in schizophrenia. Schizophrenia Research 5:167–76.CrossRefGoogle ScholarPubMed
Petty, L. K., Ornitz, E. M., Michelman, J. G. & Zimmerman, E. G. (1984) Autistic children who become schizophrenic. Archives of General Psychiatry 41:129–35.CrossRefGoogle ScholarPubMed
Tantam, D. (1988) Asperger's syndrome. Journal of Child Psychology and Psychiatry 29:245–55.CrossRefGoogle ScholarPubMed
Tordjman, S., Anderson, G., Macbride, A., Hetzig, M., Snow, M., Hall, L., Ferrari, P. & Cohen, D. J. (1997) Plasma B. endorphin, adrenocorticotropin hormone and cortisol in autism. Journal of Child Psychology and Psychiatry 38(6):705–16.CrossRefGoogle ScholarPubMed
Tordjman, S., Antoine, C., Cohen, D. J., Gauvain-Piquard, A., Carlier, M., Roubertoux, P. L. & Ferrari, P. (1999) Etude des conduites autoagressives, de la réactivité à la douleur et de leurs interrelations chez les enfants autistes [Study of the relationships between self-injurious behavior and pain reactivity in infantile autism]. L'Encéphale 25:122–34.Google Scholar
Tordjman, S., Drapier, D., Bonnot, O., Graignic, R., Fortes, S., Cohen, D., Millet, B., Laurent, C. & Roubertoux, P. L. (2007) Animal models relevant to schizophrenia and autism: Validity and limitations. Behavior Genetics 37(1):61–78.CrossRefGoogle ScholarPubMed
Tordjman, S., Gutknecht, L., Carlier, M., Spitz, E., Antoine, C., Slama, F., Carsalade, V., Cohen, D. J., Ferrari, P., Roubertoux, P. L. & Anderson, G. M. (2001) Role of the serotonin transporter gene in the behavioral expression of autism. Molecular Psychiatry 6:434–39.CrossRefGoogle ScholarPubMed
Van Den Bosch, R. J., Van Asma, M. J., Rombouts, R. & Louwerens, J. W. (1992) Coping style and cognitive dysfunction in schizophrenic patients. British Journal of Psychiatry Supplement 18:123–28.CrossRefGoogle Scholar
Van Engleand, H., & Van Der Gaag, R. J. (1994) MCDD in childhood: A precursor of schizophrenic spectrum disorders. Schizophrenia Research 11:197.Google Scholar
Watson, S. J., Akil, H., Berger, P. A. & Barchas, J. D. (1979) Some observations on the opiate peptides and schizophrenia. Archives of General Psychiatry 36:35–41.CrossRefGoogle ScholarPubMed
Wiedl, K. H. (1992) Assessment of coping with schizophrenia. Stressors, appraisals, and coping behaviour. British Journal of Psychiatry Supplement 18:114–22.CrossRefGoogle Scholar
Yan, W. L., Guan, X. Y., Green, E. D., Nicolson, R., Yap, T. K., Zhang, J., Jacobsen, L. K., Krasnewich, D. M., Kumra, S., Lenane, M. C., Gochman, P., Damschroder-Williams, P. J., Esterling, L. E., Long, R. T., Martin, B. M., Sitransky, E., Rapoport, J. L. & Ginns, E. I. (2000) Childhood-onset schizophrenia/autistic disorder and t (1;7) reciprocal translocation: Identification of a BAC contig spanning the translocation breakpoint al 7q21. American Journal of Medical Genetics 96(6):749–53.3.0.CO;2-K>CrossRefGoogle Scholar