The present response elaborates and defends the main theses advanced in the target article: namely, that in order to provide an evolutionary account of brain lateralization, we should consider advantages and disadvantages associated both with the individual possession of an asymmetrical brain and with the alignment of the direction of lateralization at the population level. We explain why we believe that the hypothesis that directional lateralization evolved as an evolutionarily stable strategy may provide a better account than alternative hypotheses. We also further our discussion of the influence of stimulation and experience in early life on lateralization, and thereby show that our hypothesis is not deterministic. We also consider some novel data and ideas in support of our main thesis.