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A Critique of Clark's Frightening Xenotransplantation Scenario

Published online by Cambridge University Press:  01 January 2021

Abstract

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Type
Commentary
Copyright
Copyright © American Society of Law, Medicine and Ethics 1999

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References

Clark, M.A., “This Little Piggy Went to Market: The Xenotransplantation and Xenozoonose Debate,” Journal of Law, Medicine & Ethics, 27 (1999): 137–52.Google Scholar
Id. at 137.Google Scholar
See id. at 138, 143, 139, 144.Google Scholar
See Platt, J.L., “New Directions for Organ Transplantation,” Nature, 392, Supp. (1998): A11–A17; and Weiss, R.A., “Science, Medicine, and the Future: Xenotransplantation,” British Medical Journal, 317 (1998): 931–32.Google Scholar
See Clark, supra note 1, at 138.Google Scholar
See Ranjit, J. Artrip, J.H. Michler, R.E., “Genetically Engineered Organs,” Advances in Cardiac Surgery, 10 (1998): 229–44.Google Scholar
See Vanderpool, H.Y., “Critical Ethical Issues in Clinical Trials with Xenotransplants,” Lancet, 351 (1998): 1347–50.Google Scholar
See Chapman, L.E. et al., “Xenotransplantation and Xenogeneic Infections,” N. Engl. J. Med., 333 (1995): 1498–501.Google Scholar
See Allan, J.S., “Xenograft Transplantation and the Infectious Disease Conundrum,” ILAR Journal, 37 (1995): 37–48; Weigler, B.J., “Biology of B Virus in Macaque and Human Hosts: A Review,” Clinical Infectious Disease, 14 (1992): 5567; Heneine, W et al., “Identification of a Human Population Infected with Simian Foamy Viruses,” Nature Medicine, 4 (1998): 403–07; and “Guidance for Industry: Public Health Issues Posed by the Use of Nonhuman Primate Xenografts in Humans,” 64 Fed. Reg. 16,743–44 (1999).Google Scholar
64 Fed. Reg. 16,743–44.Google Scholar
See Le Tissier, P. et al., “Two Sets of Human-Trophic Pig Retrovirus,” Nature, 389 (1997): 681–82; and Patience, C. Takeuchi, Y. Weiss, R.A., “Infection of Human Cells by an Endogenous Retrovirus of Pigs,” Nature Medicine, 3 (1997): 282–86.Google Scholar
See Letter from Risso, S.T., “FDA Letter to Sponsors of Porcine Xenograft” (Oct. 16, 1997).Google Scholar
See Heneine, W. et al., “No Evidence of Infection with Porcine Endogenous Retrovirus in Recipients of Porcine Islet-Cell Xenografts,” Lancet, 352 (1998): 695–99; and Patience, C. et al., “No Evidence of Pig DNA or Retroviral Infection in Patients with Short-Term Extracorporeal Connection to Pig Kidneys,” Lancet, 352 (1998): 699701.Google Scholar
See Martin, U. et al., “Expression of Pig Endogenous Retrovirus by Primary Porcine Endothelial Cells and Infection of Human Cells,” Lancet, 352 (1998): 692–94; and Martin, U. et al., “Porcine Endogenous Retrovirus (PERV) Was Not Transmitted from Transplanted Porcine Endothelial Cells to Baboons In Vivo,” Transplantation International, 11 (1998): 247–51.CrossRefGoogle Scholar
See Clark, supra note 1, at 145.Google Scholar
See Committee on Xenograft Transplantation Ethical Issues and Public Policy, Institute of Medicine, Xenotransplantation: Science, Ethics, and Public Policy (Washington, D.C.: National Academy Press, 1996) [hereinafter Institute of Medicine]; and Nuffield Council on Bioethics, Animal-to-Human Transplants: The Ethics of Xenotransplantation (London: Nuffield Council on Bioethics, 1996).Google Scholar
See Vanderpool, supra note 7; Institute of Medicine, supra note 16; and McCarthy, C.R., “Ethical Aspects of Animal-to-Human Xenografts,” ILAR Journal, 37 (1995): 39.Google Scholar
See Clark, supra note 1, at 148.Google Scholar
See id. at 144.Google Scholar
See Zaner, R.M., “Surprise! You're Just Like Me?: Reflections on Cloning, Eugenics, and Other Utopias,” in Humber, J.M. Almeder, R.F., eds., Human Cloning (Totowa: Humana Press, 1998): 105–51.Google Scholar
See Clark, supra note 1, at 141.Google Scholar
See Caplan, A.L., “Is Xenografting Morally Wrong?,” Transplantation Proceedings, 24 (1992): 722–27.Google Scholar
See Buckle, S., “Natural Law,” in Singer, P., ed., A Companion to Ethics (Oxford: Basil Blackwell, 1993): 161–74.Google Scholar
Id. at 172.Google Scholar
See Nuffield Council on Bioethics, supra note 16; and Veatch, R.M., “The Ethics of Xenografts,” Transplantation Proceedings, 3 (1986): 9397.Google Scholar
See Clark, supra note 1, at 137.Google Scholar
Id. at 148.Google Scholar
See Ranjit, Artrip, Michler, supra note 6.Google Scholar
See Weiss, supra note 4.Google Scholar
See Ranjit, Artrip, Michler, supra note 6.Google Scholar
See Institute of Medicine, supra note 16, at 57–61.Google Scholar
Id. at 71.Google Scholar
See Platt, supra note 4; and Dorling, A., “Clinical Xenotransplantation of Solid Organs,” Lancet, 349 (1997): 867–75.Google Scholar