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Modeling Man: The Monkey Colony at the Carnegie Institution of Washington’s Department of Embryology, 1925–1971

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Abstract

Though better recognized for its immediate endeavors in human embryo research, the Carnegie Department of Embryology also employed a breeding colony of rhesus macaques for the purposes of studying human reproduction. This essay follows the course of the first enterprise in maintaining a primate colony for laboratory research and the overlapping scientific, social, and political circumstances that tolerated and cultivated the colony’s continued operation from 1925 until 1971. Despite a new-found priority for reproductive sciences in the United States, by the early 1920s an unfertilized human ovum had not yet been seen and even the timing of ovulation remained unresolved. Progress would require an organized research approach that could extend beyond the limitations of working with scant and inherently restrictive human subjects or with common lab mammals like mice. In response, the Department of Embryology, under the Carnegie Institution of Washington (CIW), instituted a novel methodology using a particular primate species as a surrogate in studying normal human reproductive physiology. Over more than 40 years the monkey colony followed an unpremeditated trajectory that would contribute fundamentally to discoveries in human reproduction, early embryo development, reliable birth control methods, and to the establishment of the rhesus macaque as a common model organism.

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References

  • Abir-Am, Pnina Geraldine. 2001. “Molecular Biology in the Context of British, French, and American Cultures.” International Social Science Journal 53(168): 187–199.

    Article  Google Scholar 

  • Alexander, Nancy J. 1978. “Preface.” Nancy J. Alexander (ed.), Animal Models for Research on Contraception and Fertility. Chicago: Northwestern University.

    Google Scholar 

  • Allen, Edgar (ed.). 1932. Sex and Internal Secretions: A Survey of Recent Research. Baltimore: Williams and Wilkins.

    Google Scholar 

  • Allen, Garland E. 1975. Life Science in the Twentieth Century. New York: Wiley.

    Google Scholar 

  • Allen, Garland E. 2007. “A Century of Evo-Devo: The Dialectics of Analysis and Synthesis in Twentieth Century Life Science.” Manfred D. Laubichler and Jane Maienschein (eds.), From Embryology to Evo-Devo. Massachusetts: MIT Press, pp. 123–168.

    Google Scholar 

  • American Anti-Vivisection Society. 1889. Illustrations of Vivisection; Or, Experiments on Living Animals, from the Works of Physiologists. Philadelphia: American Anti-Vivisection Society.

    Google Scholar 

  • 1925. “Monkeys and Men Compared in Talk: Some of Apes Surpass Humans in Physical Development (Schultz at Lecture).” Baltimore Sun. November 18, p. 3.

  • 1950. “Skeletons in His Closet – Schultz is an Authority on Monkey Business.” Baltimore Sun. April 30, p. MG8.

  • Bartelmez, George W., with the collaboration of Corner, George W. and Hartman, Carl G. 1951. “Cyclic Changes in the Endometrium of the Rhesus Monkey (Macaca mulatta).” Contributions to Embryology 34: 99–144.

  • Bowler, Peter J. 2003. Evolution: The History of an Idea. Berkeley: University of California Press.

    Google Scholar 

  • Carnegie Institution. 1978. “Profile of a Carnegie Embryologist: Elizabeth Ramsey.” Newsletter. February 1978, pp. 4–5.

  • Carnegie Institution of Washington. 1940. Descriptive Pamphlet, 20th Issue. Washington, DC: Carnegie Institution of Washington.

  • Carnegie Institution Year Books 1-70, 1901–1971.

  • Chesler, Ellen. 1992. Woman of Valor: Margaret Sanger and the Birth Control Movement in America. New York: Simon and Schuster.

    Google Scholar 

  • Churchill, Frederick B. 1998. “The Modern Evolutionary Synthesis and the Biogenetic Law.” Ernst Mayr and William B. Provine (eds.), The Evolutionary Synthesis: Perspectives on the Unification of Biology. London: Harvard University Press, pp. 112–122.

    Google Scholar 

  • Clark, Constance Areson. 2008. God – or Gorilla: Images of Evolution in the Jazz Age. Baltimore: Johns Hopkins University Press.

    Google Scholar 

  • Clarke, Adele E. 1987. “Research Materials and Reproductive Science.” Gerald L. Geison (ed.), Physiology in the American Context, 1850–1940. Bethesda: American Physiological Society.

    Google Scholar 

  • Clarke, Adele E. 1998. Disciplining Reproduction: Modernity, American Life Sciences, and “the Problems of Sex”. Berkeley: University of California Press.

    Google Scholar 

  • Clarke, Adele E. 2000. “Maverick Reproductive Scientists and the Production of Contraceptives, 1915–2000.” Ann Rudinow Saetnan and Marta Stefania Maria Kirejczyk (eds.), Bodies of Technology: Women’s Involvement with Reproductive Medicine. Columbus: Ohio State University Press, pp. 51–165.

    Google Scholar 

  • Cobbe, Frances Power. 1875. “The Moral Aspects of Vivisection.” New Quarterly Magazine 4: 222–237.

    Google Scholar 

  • Cobbe, Frances Power and Bryan, Benjamin. 1890. Vivisection in America, 4th ed. London: Swan, Sonnenschein and Company.

    Google Scholar 

  • Corner, George W. 1923a. “Oestrus, Ovulation, and Menstruation.” Physiological Reviews 3(4): 457–482.

    Google Scholar 

  • Corner, George W. 1923b. “Ovulation and Menstruation in Macacus rhesus.” Contributions to Embryology 15: 73–101.

    Google Scholar 

  • Corner, George W. 1939. “The Ovarian Hormones and Experimental Menstruation.” American Journal of Obstetrics and Gynecology 38(5): 862–871.

    Google Scholar 

  • Corner, George W. 1944. Ourselves Unborn: An Embryologists Essay on Man. New Haven: Yale University Press.

    Google Scholar 

  • Corner, George W. 1958. Anatomist at Large: An Autobiography and Selected Essays. New York: Basic Books.

    Google Scholar 

  • Corner, George W. 1981. The Seven Ages of a Medical Scientist. Philadelphia: University of Pennsylvania Press.

    Google Scholar 

  • Corner, George W. and Allen, Willard M. 1929. “Physiology of the Corpus Luteum 2. Production of a Special Uterine Reaction (Progestational Proliferation) by Extracts of the Corpus Luteum.” American Journal of Physiology 88: 326–329.

    Google Scholar 

  • Corner, George W., with the Collaboration of Hartman, Carl G. and Bartelmez, George W. 1945. “Development, Organization, and Breakdown of the Corpus Luteum in the Rhesus Monkey.” Contributions to Embryology 31: 117–146

  • Critchlow, Donald T. 1996. The Politics of Abortion and Birth Control in Historical Perspective. University Park: Pennsylvania State University Press.

    Google Scholar 

  • Darwin, Charles. 1859. The Origin of Species. London: John Murray.

    Google Scholar 

  • Dukelow, W. Richard and Whitehair, Leo A. 1995. “A Brief History of the Regional Primate Centers.” Comparative Pathology Bulletin 27(3): 1–2.

    Google Scholar 

  • Flexner, Abraham. 1910. Medical Education in the United States and Canada: A Report to the Carnegie Foundation for the Advancement of Teaching. New York: Carnegie Foundation for the Advancement of Teaching.

    Google Scholar 

  • Frank, Robert G. Jr. 1987. “American Physiologists in German Laboratories, 1865–1914.” Gerald L. Geison (ed.), Physiology in the American Context, 1850–1940. Bethesda: American Physiological Society.

    Google Scholar 

  • Fridman, Éman Petrovich and Nadler, Ronald D. 2002. Medical Primatology: History, Biological Foundations and Applications. New York: Taylor and Francis.

    Google Scholar 

  • Gilbert, Scott F. 2003. “The Morphogenesis of Evolutionary Developmental Biology.” International Journal of Developmental Biology 47: 467–477.

    Google Scholar 

  • Haeckel, Ernst. 1868. Natürliche Schöpfungsgeschichte. Berlin: Georg Reimer.

    Google Scholar 

  • Hamburger, Viktor. 1998. “Embryology and the Modern Synthesis in Evolutionary Theory.” Ernst Mayr and William B. Provine (eds.), The Evolutionary Synthesis: Perspectives on the Unification of Biology. London: Harvard University Press, pp. 97–111.

    Google Scholar 

  • Hanson, Elizabeth. 2004. “How Rhesus Monkeys Became Laboratory Animals.” Jane Maienschein, Marie Glitz and Garland E. Washington (eds.), Centennial History of the Carnegie Institution of Washington, Vol. 5: The Department of Embryology. Cambridge: Cambridge University Press, pp. 63–81.

    Google Scholar 

  • Hartman, Carl G. 1932. “Studies in the Reproduction of the Monkey Macacus (Pithecus) rhesus, with Special Reference to Menstruation and Pregnancy.” Contributions to Embryology 23: 1–161.

    Google Scholar 

  • Hartman, Carl G. 1933a. “Housing and Care.” Carl G. Hartman and William L. Straus (eds.), Anatomy of the Rhesus Monkey. New York: Hafner.

    Google Scholar 

  • Hartman, Carl G. 1933b. “Catholic Advice on the Safe Period.” Birth Control Review 17: 117–119.

    Google Scholar 

  • Hartman, Carl G. 1939. “Studies on Reproduction in the Monkey and Their Bearing on Gynecology and Anthropology.” Endocrinology 25: 670–682.

    Article  Google Scholar 

  • Hartman, Carl G. 1959. “Annotated List of Published Reports on Clinical Trials with Contraceptives.” Fertility and Sterility 10(2): 177–189.

    Google Scholar 

  • Hertig, Arthur T., Rock, John and Adams, Eleanor C. 1956. “A Description of 34 Human Ova Within the First 17 Days of Development.” American Journal of Anatomy 98(3): 435–494.

    Article  Google Scholar 

  • Heuser, Chester H. and Streeter, George L. 1941. “Development of the Macaque Embryo.” Contributions to Embryology 29: 15–55.

    Google Scholar 

  • His, Wilhelm. 1886. “Die Entwicklung der zoologischen Station in Neapel und das wachsende Bedürfniss nach wissenschaftlichen Centralanstalten.” Biologisches Centralblatt 6: 545–554.

    Google Scholar 

  • Hogden, Gary D. 1978. “Primate Models for Pregnancy Hormone Secretion in Man: Fetal, Maternal, and Placental Factors.” Nancy J. Alexander (ed.), Animal Models for Research on Contraception and Fertility. Chicago: Northwestern University.

    Google Scholar 

  • Hopwood, Nick. 2000. “Producing Development: The Anatomy of Human Embryos and the Norms of Wilhelm His.” Bulletin for the History of Medicine 74: 29–79.

    Google Scholar 

  • Hopwood, Nick. 2007. “A History of Normal Plates, Tables and Stages in Vertebrate Embryology.” International Journal of Developmental Biology 51(1): 1–26.

    Article  Google Scholar 

  • King, Frederick A., et al. 1988. “Primates.” Science 240(4858): 1475–1482.

    Article  Google Scholar 

  • Landecker, Hannah. 2004. “The Lewis Films.” Jane Maienschein, Marie Glitz and Garland E. Washington (eds.), Centennial History of the Carnegie Institution of Washington, Vol. 5: The Department of Embryology. Cambridge: Cambridge University Press, pp. 117–144.

    Google Scholar 

  • Larson, Edward J. 2006. Summer for the Gods: The Scopes Trial and America’s Continuing Debate Over Science and Religion. New York: Basic Books.

    Google Scholar 

  • Lederer, Susan E. 1997. Subjected to Science: Human Experimentation in America Before the Second World War. Baltimore: Johns Hopkins University Press.

    Google Scholar 

  • Lewis, Warren H. and Hartman, Carl G. 1933. “Early Cleavage Stages of the Eggs of the Monkey (Macacus rhesus).” Contributions to Embryology 24: 187–201.

    Google Scholar 

  • Ludmerer, Kenneth. 1985. Learning to Heal: The Development of American Medical Education. New York: Basic Books.

    Google Scholar 

  • Macaulay, James. 1884. Vivisection: Is it Scientifically Useful or Morally Justifiable? A Prize Essay. Vivisection Society: The Anti.

    Google Scholar 

  • Mall, Franklin P. 1913. “A Plea for an Institute of Human Embryology.” Journal of the American Medical Association 60(21): 1–11.

    Google Scholar 

  • Markee, J. Eldridge. 1940. “Menstruation in Intraocular Endometrial Transplants in the Rhesus Monkey.” Contributions to Embryology 28: 219–308.

    Google Scholar 

  • Marks, Lara. 2001. Sexual Chemistry: A History of the Contraceptive Pill. New Haven: Yale University Press.

    Google Scholar 

  • Mayr, Ernst. 1988. Toward a New Philosophy of Biology: Observations of an Evolutionist. Boston: Harvard University Press.

    Google Scholar 

  • Mayr, Ernst. 1993. “What was the Evolutionary Synthesis?” Trends in Ecology & Evolution 8(1): 31–34.

    Article  Google Scholar 

  • Meyer, Arthur William. 1918. “Franklin Paine Mall: An Appreciation.” Journal of the American Medical Association 70: 121–123.

    Article  Google Scholar 

  • Morgan, Lynn M. 2002. “‘Properly Disposed of’: A History of Embryo Disposal and the Changing Claims on Fetal Remains.” Medical Anthropology 21(3 and 4): 247–274.

    Article  Google Scholar 

  • 1925a. “Twenty Monkeys for Study of Evolution Are Coming to Johns Hopkins from Asia.” New York Times. October 8, p. 1.

  • 1925b. “Monkeys to Serve Mankind; Embryological Evolution of Human Growth will be Studied in New Colony of Apes at the Johns Hopkins Medical School.” New York Times. November 1, p. xx4.

  • 1940. “Wanted: More Monkeys.” New York Times. December 6, p. 144.

  • Noe, Adrianne. 2004. “The Human Embryo Collection.” Jane Maienschein, Marie Glitz and Garland E. Washington (eds.), Centennial History of the Carnegie Institution of Washington, Vol. 5: The Department of Embryology. Cambridge: Cambridge University Press, pp. 21–61.

    Google Scholar 

  • Numbers, Ronald L. 1992. The Creationists: From Scientific Creationism to Intelligent Design. Harvard: Harvard University Press.

    Google Scholar 

  • Ortho Research Foundation. 1953. To Honor Carl Gottfried Hartman: Distinguished Scientist, Educator and Author. Raritan, NJ: Ortho Research Foundation.

  • Provine, William B. 1998. “Epilogue.” Ernst Mayr and William B. Provine (eds.), The Evolutionary Synthesis: Perspectives on the Unification of Biology. London: Harvard University Press, pp. 399–412.

    Google Scholar 

  • Ramsey, Elizabeth M. 1954. “Circulation in the Maternal Placenta of Primates.” American Journal of Obstetrics and Gynecology 67(1): 1–14.

    Google Scholar 

  • Ramsey, Elizabeth M. 1972. “Evaluation of Macaca mulatta as an Experimental Model for Studies of Primate Reproduction.” Medical Primatology, from the Proceedings of the 3rd Conference of the Experimental Medicine and Surgery in Primates, Lyons, Part I, pp. 308–316

  • Ramsey, Elizabeth M. 1991. “Classics Revisited: The Yale Embryo.” Placenta 12: 87–89.

    Article  Google Scholar 

  • Rawlins, Richard G. and Kessler, Matt J. 1986. The Cayo Santiago Macaques: History, Behavior, and Biology. New York: State University of New York Press.

    Google Scholar 

  • Rock, John and Menkin, Miriam F. 1944. “In Vitro Fertilization and Cleavage of Human Ovarian Eggs.” Science 100: 105–107.

    Article  Google Scholar 

  • Rowan, Andrew N. 1984. Of Mice, Models and Men: A Critical Evaluation of Animal Research. New York: State University of New York Press.

    Google Scholar 

  • Sabin, Florence R. 1934a. “Franklin Paine Mall, 1862–1917.” National Academy of Sciences Biographical Memoirs 16: 64–122.

    Google Scholar 

  • Sabin, Florence R. 1934b. Franklin Paine Mall: The Story of a Mind. Baltimore: Johns Hopkins Press.

    Google Scholar 

  • Schultz, Adolf H. 1925. “Embryological Evidence of the Evolution of Man.” Journal of the Washington Academy of Science 15:247–263

    Google Scholar 

  • Skloot, Rebecca. 2010. The Immortal Life of Henrietta Lacks. New York: Crown Publishers.

    Google Scholar 

  • Streeter, George L. 1924. “An Appeal for Human Embryos.” Carnegie Laboratory of Embryology Mailing.

  • Streeter, George L., prepared for publication by Heuser, Chester H. and Corner, George W. 1951. “Developmental Horizons in Human Embryos, Age Groups XI to XXIII: Collected Papers from the Contributions to Embryology Published by the Carnegie Institution of Washington.” Contributions to Embryology 34: 165–196

  • The American Humane Education Society. 1891. Vivisection: Five Hundred Dollar Prize Essays. Boston: The American Humane Education Society.

    Google Scholar 

  • Todes, Daniel. 2000. Ivan Pavlov: Exploring the Animal Machine. New York: Oxford University Press.

    Google Scholar 

  • Tone, Andrea. 2002. Devices and Desires: A History of Contraceptives in America. New York: Hill and Wang.

    Google Scholar 

  • United States Congress. 1900. Vivisection: Hearing Before the Senate Committee of the District of Columbia. Washington, DC: Government Printing Office.

    Google Scholar 

  • Unti, Bernard and Rowan, Andrew N. 2001. “A Social History of Postwar Animal Protection.” Deborah J. Salem and Andrew N. Rowan (eds.), The State of the Animals. Washington, DC: Humane Society Press, pp. 21–33.

    Google Scholar 

  • Vollman, Rudolf F. 1965. Fifty Years of Research on Mammalian Reproduction: A Bibliography of the Scientific Publications of Carl G. Hartman. Washington, DC: U.S. Department of Health, Education, and Welfare. Public Health Service.

    Google Scholar 

  • Webb, George E. 1994. The Evolution Controversy in America. Lexington: University Press of Kentucky.

    Google Scholar 

  • Welch, William H. 1898. “Objections to the Antivivisection Bill now Before the Senate of the United States.” Journal of the American Medical Association 30(6): 285–290.

    Article  Google Scholar 

  • Whitman, Charles Otis. 1902. “A Biological Farm for the Experimental Investigation of Heredity, Variation, and Evolution and for the Study of Life Histories, Habits, Instincts, and Intelligence.” Science 16: 504–510.

    Article  Google Scholar 

  • Wislocki, George B. and Streeter, George L. 1938. “On the Placentation of the Macaque (Macaca mulatta), from the Time of Implantation Until the Formation of the Definitive Placenta.” Contributions to Embryology 27: 1–66.

    Google Scholar 

  • Yerkes, Robert M. 1916. “Provision for the Study of Monkeys and Apes.” Science 43: 231–234.

    Article  Google Scholar 

  • Yerkes, Robert M. 1925. Almost Human. New York: The Century Company.

    Google Scholar 

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  1. National Museum of Health and Medicine, 6900 Georgia Ave, NW, Building 54, Washington, DC, 20307, USA

    Emily K. Wilson

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  1. Emily K. Wilson
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Correspondence to Emily K. Wilson.

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All images are from the Human Developmental Anatomy Center, National Museum of Health and Medicine.

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Wilson, E.K. Modeling Man: The Monkey Colony at the Carnegie Institution of Washington’s Department of Embryology, 1925–1971. J Hist Biol 45, 213–251 (2012). https://doi.org/10.1007/s10739-011-9282-8

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