This paper is a preliminary study focused on the astronomical manuscript Marcianus latinus VIII.31 (2614) and its socio-historical context of use and production, the Venetian colony of Crete in the 15th century. It is a relevant source for the study of scientific interactions in colonial, multilinguistic, and interreligious contexts in the Eastern Mediterranean for at least two reasons: (a) it contains an unpublished translation into Latin of a popular Byzantine handbook on how to use a set of astronomical tables stemming (...) from Islamic sources, namely the so-called Paradosis of the Persian Tables, a work extensively copied and annotated by very significant Byzantine and Jewish scholars active in Constantinople; and (b) it provides evidence of a Byzantine product being the object of exchange in the interactions between Christians and Jews in the Cretan territory under Venetian rule. (shrink)