This chapter argues in favour of three interrelated points. First, I argue that demonstration (as expression of scientific knowledge) is fundamentally defined as knowledge of the appropriate cause for a given explanandum: to have scientific knowledge of the explanandum is to explain it through its fully appropriate cause. Secondly, I stress that Aristotle’s notion of cause has a “triadic” structure, which fundamentally depends on the predicative formulation (or “regimentation”) of the explanandum. Thirdly, I argue that what has motivated Aristotle to choose the syllogism as a demonstrative tool was precisely the fact that syllogisms are apt to express causal relations in their triadic structure. Instead of complaining against Aristotle’s preference for the syllogisms as demonstrative tools, I argue that Aristotle was fully aware of the advantages of regimenting the explanandum into a predication. One of these advantages is to abandon a purely extensional standpoint and to highlight the importance of the notion of relevancy in explanation.