Neural transplants for parkinson's disease: what are the issues?

Poiesis and Praxis 4 (2):129-143 (2006)
Parkinson’s disease (PD) is a common neurodegenerative disorder of the nervous system that affects about 1 in 800 people and for which we have symptomatic but not curative therapies. At the core of the disease is the loss of a specific population of dopaminergic neurons within the brain, and replacement of dopamine through drug therapies has provided clinically significant benefit for many patients. However this therapy only ever offers a temporary amelioration of symptoms and with time this symptomatic therapy becomes less efficacious and produces its own unique side-effects. As a result more effective curative therapies have been sought, including the use of cell based therapies to replace the lost dopaminergic neurons. In this review I am going to discuss PD and its possible repair using neural transplants. In particular I am going to discuss which type of cells are best considered as a reparative therapy, where they should be transplanted in the brain, when in the disease course and in which type of patient. By considering these issues, I hope to be able to make some recommendations as to the future use of this approach in PD.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1007/s10202-006-0021-8
 Save to my reading list
Follow the author(s)
Edit this record
My bibliography
Export citation
Find it on Scholar
Mark as duplicate
Request removal from index
Revision history
Download options
Our Archive

Upload a copy of this paper     Check publisher's policy     Papers currently archived: 30,781
Through your library
References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles
The Biochemical Bases of the Placebo Effect.Raúl de la Fuente-Fernández & A. Jon Stoessl - 2004 - Science and Engineering Ethics 10 (1):143-150.
Does Catatonia Have a Specific Brain Biology?Bernhard Bogerts - 2002 - Behavioral and Brain Sciences 25 (5):580-581.
The Disease Status of Catatonia.Irwin Savodnik - 2002 - Behavioral and Brain Sciences 25 (5):590-591.
The Burden of Dementia: A Medical and Research Perspective.Piero Antuono & Jan Beyer - 1999 - Theoretical Medicine and Bioethics 20 (1):3-13.
Added to PP index

Total downloads
13 ( #366,005 of 2,199,652 )

Recent downloads (6 months)
1 ( #300,206 of 2,199,652 )

How can I increase my downloads?

Monthly downloads
My notes
Sign in to use this feature