The manipulability of what? The history of G-protein coupled receptors

Biology and Philosophy 32 (6):1317-1339 (2017)

Authors
Ann-Sophie Barwich
Indiana University, Bloomington
Abstract
This paper tells the story of G-protein coupled receptors, one of the most important scientific objects in contemporary biochemistry and molecular biology. By looking at how cell membrane receptors turned from a speculative concept into a central element in modern biochemistry over the past 40 years, we revisit the role of manipulability as a criterion for entity realism in wet-lab research. The central argument is that manipulability as a condition for reality becomes meaningful only once scientists have decided how to conceptually coordinate measurable effects distinctly to a specific object. We show that a scientific entity, such as GPCRs, is assigned varying degrees of reality throughout different stages of its discovery. The criteria of its reality, we further claim, cannot be made independently of the question about how this object becomes a standard by which the reality of neighbouring elements of enquiry is evaluated.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1007/s10539-017-9608-9
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 39,940
Through your library

References found in this work BETA

Robustness, Discordance, and Relevance.Jacob Stegenga - 2009 - Philosophy of Science 76 (5):650-661.
Biographies of Scientific Objects.Lorraine Daston - 2002 - History and Philosophy of the Life Sciences 23 (3/4):551-551.

View all 16 references / Add more references

Citations of this work BETA

Add more citations

Similar books and articles

Experimenting on and Experimenting With: Polywater and Experimental Realism.William J. Mckinney - 1991 - British Journal for the Philosophy of Science 42 (3):295-307.
An Abductive Theory of Constitution.Michael Baumgartner & Lorenzo Casini - 2017 - Philosophy of Science 84 (2):214-233.

Analytics

Added to PP index
2017-12-19

Total views
19 ( #417,332 of 2,235,461 )

Recent downloads (6 months)
5 ( #364,871 of 2,235,461 )

How can I increase my downloads?

Downloads

My notes

Sign in to use this feature