Abstract
In the last years, the debate on the therapeutic use of psychoactive drugs and compounds has intensified and has attracted a progressively growing body of research as well as of conferences and training courses. This is anticipated to revolutionize future mental health care. However, a medieval obscurantist climate remains that hinders further advances in the field. The research field of psychoactive drugs, despite its promises, is characterized by a number of challenges which, in the future, should be addressed, concerning, for instance, their potential therapeutic use. There is a concrete possibility to revitalize the use of these substances by bridging past and present, combining ancient knowledge and modern science to serve new therapeutic paradigms.