On MicroRNA and the Need for Exploratory Experimentation in Post-Genomic Molecular Biology


Abstract
This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular biology. The material on microRNAs is important in its own right: it provides important insight into the extreme complexity of regulatory networks involving components made of DNA, RNA, and protein. These networks play a central role in regulating development of multicellular organisms and illustrate the importance of epigenetic as well as genetic systems in evolution and development. The examination of these matters yields principled arguments for the historicity of the functions of key biological molecules and for the indispensability of exploratory experimentation in contemporary molecular biology as well as some insight into the complex interplay between exploratory experimentation and hypothesis-driven science. This latter result is not only important for philosophy of science, but also of practical importance for the evaluation of grant proposals, although the elaboration of this latter claim must be left for another occasion
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What Was Classical Genetics?C. Kenneth Waters - 2004 - Studies in History and Philosophy of Science Part A 35 (4):783-809.
Experiments in History and Philosophy of Science.Friedrich Steinle - 2002 - Perspectives on Science 10 (4):408-432.
Varieties of Exploratory Experimentation in Nanotoxicology.Kevin Elliott - 2007 - History and Philosophy of the Life Sciences 29 (3):313 - 336.

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Why Do Funding Agencies Favor Hypothesis Testing?Chris Haufe - 2013 - Studies in History and Philosophy of Science Part A 44 (3):363-374.

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