History and Philosophy of the Life Sciences 29 (3):285 - 311 (2007)
This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular biology. The material on microRNAs is important in its own right: it provides important insight into the extreme complexity of regulatory networks involving components made of DNA, RNA, and protein. These networks play a central role in regulating development of multicellular organisms and illustrate the importance of epigenetic as well as genetic systems in evolution and development. The examination of these matters yields principled arguments for the historicity of the functions of key biological molecules and for the indispensability of exploratory experimentation in contemporary molecular biology as well as some insight into the complex interplay between exploratory experimentation and hypothesis-driven science. This latter result is not only important for philosophy of science, but also of practical importance for the evaluation of grant proposals, although the elaboration of this latter claim must be left for another occasion
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
References found in this work BETA
No references found.
Citations of this work BETA
Stretching the Traditional Notion of Experiment in Computing: Explorative Experiments.Viola Schiaffonati - 2016 - Science and Engineering Ethics 22 (3):647-665.
The Fate of Darwinism: Evolution After the Modern Synthesis.David J. Depew & Bruce H. Weber - 2011 - Biological Theory 6 (1):89-102.
Why Do Funding Agencies Favor Hypothesis Testing?Chris Haufe - 2013 - Studies in History and Philosophy of Science Part A 44 (3):363-374.
Inductivism in Practice: Experiment in John Herschel's Philosophy of Science.Aaron D. Cobb - 2012 - Hopos: The Journal of the International Society for the History of Philosophy of Science 2 (1):21-54.
Fritz Allhoff, Patrick Lin, James Moor, and John Weckert (Eds.):Nanoethics: The Ethical and Social Implications of Nanotechnology,:Nanoethics: The Ethical and Social Implications of Nanotechnology.Kevin C. Elliott - 2008 - Philosophy of Science 75 (3):405-408.
Similar books and articles
From "Scraps and Fragments" to "Whole Organisms" : Molecular Biology, Clinical Research, and Post Genomic Bodies.Susan E. Kelly - 2006 - In Paul Atkinson (ed.), New Genetics, New Indentities. Routledge.
Ins and Outs of Systems Biology Vis-À-Vis Molecular Biology: Continuation or Clear Cut?Philippe De Backer, Danny De Waele & Linda Van Speybroeck - 2010 - Acta Biotheoretica 58 (1):15-49.
Review of Genes in Development: Re-Reading the Molecular Paradigm. [REVIEW]Brant Pridmore - 2008 - Biology and Philosophy 23 (4):579-586.
Naturalists, Molecular Biologists, and the Challenges of Molecular Evolution.Joel B. Hagen - 1999 - Journal of the History of Biology 32 (2):321 - 341.
From Molecules to Systems: The Importance of Looking Both Ways.Alexander Powell & John Dupré - 2009 - Studies in History and Philosophy of Biological and Biomedical Sciences 40 (1):54-64.
Arguments for Experimentation in Biology.Jane Maienschein - 1986 - PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1986:180 - 195.
Entering New Fields: Exploratory Uses of Experimentation.Friedrich Steinle - 1997 - Philosophy of Science 64 (4):74.
The Nature and Context of Exploratory Experimentation: An Introduction to Three Case Studies of Exploratory Research.C. Kenneth Waters - 2007 - History and Philosophy of the Life Sciences 29 (3):275 - 284.
Exploratory Experimentation and Scientific Practice: Metagenomics and the Proteorhodopsin Case.Maureen O'Malley - 2007 - History and Philosophy of the Life Sciences 29 (3):337 - 360.
Added to index2009-01-28
Total downloads59 ( #88,219 of 2,163,731 )
Recent downloads (6 months)3 ( #129,223 of 2,163,731 )
How can I increase my downloads?