Abstract

This essay represents a serious but fictional obituary of a scientific concept called the Threshold Dose–Response Model, which has long dominated the fields of toxicology and the broader biomedical sciences. Recent evidence indicates that the Threshold Dose–Response Model has long outlived its utility to predict low‐dose effects. In fact, so poorly does this model predict low‐dose responses that the idea arose that it should receive a symbolic burial recounting its achievements and failings, hence this obituary. BioEssays 29:686–688, 2007. © 2007 Wiley Periodicals, Inc.