Harvesting the Promise of AOPs: An assessment and recommendations

Science of the Total Environment 628:1542-1556 (2018)

Authors
Annamaria Carusi
University of Copenhagen
Giovanni De Grandis
University College London
Abstract
The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies.
Keywords Toxicology  Adverse outcomes pathways  Risk assessment  Environmental health  Chemical management  Social, ethical and legal aspects
Categories (categorize this paper)
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

Getting Scientists to Think About What They Are Doing.John Ziman - 2001 - Science and Engineering Ethics 7 (2):165-176.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

A Framework for the Ethical Impact Assessment of Information Technology.David Wright - 2011 - Ethics and Information Technology 13 (3):199-226.
The Concept of Risk: Risk Assessment and Nuclear Safety.Paul Banks Thompson - 1980 - Dissertation, State University of New York at Stony Brook
Antibiotic Resistance Due to Modern Agricultural Practices: An Ethical Perspective. [REVIEW]Joan Duckenfield - 2013 - Journal of Agricultural and Environmental Ethics 26 (2):333-350.
The Assessment of Individual Moral Goodness.Raymond B. Chiu & Rick D. Hackett - 2017 - Business Ethics: A European Review 26 (1):31-46.

Analytics

Added to PP index
2018-03-03

Total views
110 ( #73,535 of 2,271,742 )

Recent downloads (6 months)
50 ( #16,154 of 2,271,742 )

How can I increase my downloads?

Downloads

My notes

Sign in to use this feature