Mapping Development or How Molecular is Molecular Biology?

The transformation of embryology to developmental biology has been linked to the introduction of experimental approaches from molecular genetics to the study of development. This paper pursues this theme by analyzing the tools molecular biologists, moving from phage and bacterial genetics to the study of development in higher organisms, brought to their new field of investigations. The paper focuses on Sydney Brenner's move from molecular genetics to developmental biology. His attempt to turn the nematode worm Caenorhabditis elegans into a new tool for the study of development included a vast and ever expanding mapping program. Worm workers themselves did not distinguish sharply between mapping on the cellular, chromosomal or molecular level. Mapping, the paper argues, or more generally 'analytical/comparative' next to 'experimentalist' approaches (Pickstone) were not only part and parcel of Brenner's strategy to 'molecularize' the study of development, but also played a crucial role in 'classical' molecular biology
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive

Upload a copy of this paper     Check publisher's policy     Papers currently archived: 38,878
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

Mechanism Schemas and the Relationship Between Biological Theories.Tudor M. Baetu - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.
Reductionism Redux: Computing the Embryo. [REVIEW]Alex Rosenberg - 1997 - Biology and Philosophy 12 (4):445-470.
Naturalists, Molecular Biologists, and the Challenges of Molecular Evolution.Joel B. Hagen - 1999 - Journal of the History of Biology 32 (2):321 - 341.
Molecular Biology and Pauling's Immunochemistry: A Neglected Dimension.Lily E. Kay - 1989 - History and Philosophy of the Life Sciences 11 (2):211 - 219.
Molecular Ecosystems.Marco J. Nathan - 2014 - Biology and Philosophy 29 (1):101-122.
Who's Afraid of Gory Details?Sun Kyeong Yu - 2008 - Proceedings of the Xxii World Congress of Philosophy 43:215-223.
Genes Made Molecular.C. Kenneth Waters - 1994 - Philosophy of Science 61 (2):163-185.
National Politics and International Trends: EMBO and the Making of Molecular Biology in Spain (1960-1975).J. M. - 2002 - Studies in History and Philosophy of Science Part C 33 (3):473-487.
Homology in Comparative, Molecular, and Evolutionary Developmental Biology: The Radiation of a Concept.Ingo Brigandt - 2003 - Journal of Experimental Zoology (Molecular and Developmental Evolution) 299:9-17.


Added to PP index

Total views
6 ( #797,875 of 2,318,487 )

Recent downloads (6 months)
2 ( #571,679 of 2,318,487 )

How can I increase my downloads?

Monthly downloads

My notes

Sign in to use this feature