Bioessays 40 (1):1700172 (2018)

Abstract
The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. Also see the video abstract here: https://youtu.be/O5gvxVJjX18 The amygdala plays a central role in regulating many aspects of behavior in rodents and humans, from pain responding to social interaction and psychiatric function. Accumulating evidence suggests microbiota-to-amygdala communication along the gut-brain axis is a key modulator of these amygdala-dependent behaviors, with critical implications for health and disease.
Keywords anxiety  fear  gut‐brain axis  limbic system  pain  social behavior  stress
Categories (categorize this paper)
DOI 10.1002/bies.201700172
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 64,046
Through your library

References found in this work BETA

The Authors.[author unknown] - 1973 - Proceedings of the Heraclitean Society 1 (2).

Add more references

Citations of this work BETA

Add more citations

Similar books and articles

Précis of the Brain and Emotion.Edmund T. Rolls - 2000 - Behavioral and Brain Sciences 23 (2):177-191.
My Amygdala-Orbitofrontal-Circuit Made Me Do It.Bill Faw - 2000 - Consciousness and Emotion 1 (1):167-179.

Analytics

Added to PP index
2017-11-17

Total views
61 ( #176,660 of 2,454,439 )

Recent downloads (6 months)
3 ( #225,749 of 2,454,439 )

How can I increase my downloads?

Downloads

My notes