Philosophy of Science 64 (4):278 (1997)
In this paper, I examine an experimental technique, gene targeting, used for establishing genotype/phenotype relationships. Through analyzing a case study, I identify many pitfalls that may lead to false conclusions about these relationships. I argue that some of these pitfalls may seriously affect gene targeting's usefulness for associating phenotypes with genes cataloged by the Human Genome Project. This case also shows the use of gene targeted mice as model systems for studying genotype/phenotype relationships in humans. Moreover, I argue that it reveals the weakness of one attempt to draw conclusions about the biological determination of sexual and aggressive behaviors in humans
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
References found in this work BETA
No references found.
Citations of this work BETA
The Dilemma of Case Studies Resolved: The Virtues of Using Case Studies in the History and Philosophy of Science.Richard M. Burian - 2001 - Perspectives on Science 9 (4):383-404.
Similar books and articles
The Extended Replicator.Kim Sterelny, Kelly C. Smith & Michael Dickison - 1996 - Biology and Philosophy 11 (3):377-403.
Genotype–Phenotype Mapping and the End of the ‘Genes as Blueprint’ Metaphor.Massimo Pigliucci - 2010 - Philosophical Transactions Royal Society B 365:557–566.
Progress Through Evolution? An Inquiry Into the Thought of C.H. Waddington.Kai Hahlweg - 1981 - Acta Biotheoretica 30 (2):103-120.
The Units of Selection and the Structure of the Multi-Level Genome.William C. Wimsatt - 1980 - PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1980:122 - 183.
Unlocking the Black Box Between Genotype and Phenotype: Cell Condensations as Morphogenetic (Modular) Units. [REVIEW]Brian K. Hall - 2003 - Biology and Philosophy 18 (2):219-247.
Genes in the Postgenomic Era.Paul E. Griffiths & Karola Stotz - 2006 - Theoretical Medicine and Bioethics 27 (6):499-521.
Why the (Gene) Counting Argument Fails in the Massive Modularity Debate: The Need for Understanding Gene Concepts and Genotype-Phenotype Relationships.Kathryn S. Plaisance, Thomas A. C. Reydon & Mehmet Elgin - 2012 - Philosophical Psychology 25 (6):873-892.
“Molecular Gene”: Interpretation in the Right Context. [REVIEW]Degeng Wang - 2005 - Biology and Philosophy 20 (2-3):453-464.
Added to index2009-01-28
Total downloads24 ( #209,553 of 2,164,286 )
Recent downloads (6 months)3 ( #128,955 of 2,164,286 )
How can I increase my downloads?