Ins and outs of systems biology vis-à-vis molecular biology: Continuation or clear cut?

Acta Biotheoretica 58 (1):15-49 (2010)

Abstract
The comprehension of living organisms in all their complexity poses a major challenge to the biological sciences. Recently, systems biology has been proposed as a new candidate in the development of such a comprehension. The main objective of this paper is to address what systems biology is and how it is practised. To this end, the basic tools of a systems biological approach are explored and illustrated. In addition, it is questioned whether systems biology ‘revolutionizes’ molecular biology and ‘transcends’ its assumed reductionism. The strength of this claim appears to depend on how molecular and systems biology are characterised and on how reductionism is interpreted. Doing credit to molecular biology and to methodological reductionism, it is argued that the distinction between molecular and systems biology is gradual rather than sharp. As such, the classical challenge in biology to manage, interpret and integrate biological data into functional wholes is further intensified by systems biology’s use of modelling and bioinformatics, and by its scale enlargement.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1007/s10441-009-9089-6
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 38,992
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

Top-Down Causation Without Top-Down Causes.Carl F. Craver & William Bechtel - 2007 - Biology and Philosophy 22 (4):547-563.
The Century of the Gene.Evelyn Fox Keller - 2001 - Journal of the History of Biology 34 (3):613-615.
What Genes Can't Do.Lenny Moss - 2005 - Journal of the History of Biology 38 (2):383-384.

View all 21 references / Add more references

Citations of this work BETA

Mechanistic Explanation in Systems Biology: Cellular Networks.Dana Matthiessen - 2017 - British Journal for the Philosophy of Science 68 (1):1-25.

View all 7 citations / Add more citations

Similar books and articles

Experiment und Orientierung: Frühe Systeme der in vitro Proteinbiosynthese.Hans-Jörg Rheinberger - 1993 - NTM Zeitschrift für Geschichte der Wissenschaften, Technik und Medizin 1 (1):237-253.
Molecular and Systems Biology and Bioethics.Jason Scott Robert - 2007 - In David L. Hull & Michael Ruse (eds.), The Cambridge Companion to the Philosophy of Biology. Cambridge University Press.
How Evolutionary Biology Presently Pervades Cell and Molecular Biology.Michel Morange - 2010 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 41 (1):113 - 120.
Approximations, Idealizations and 'Experiments' at the Physics-Biology Interface.Darrell Patrick Rowbottom - 2008 - Studies in History and Philosophy of Biological and Biomedical Sciences 42 (2):145-154.
Mechanism Schemas and the Relationship Between Biological Theories.Tudor M. Baetu - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.

Analytics

Added to PP index
2009-10-28

Total views
83 ( #85,877 of 2,319,657 )

Recent downloads (6 months)
10 ( #102,789 of 2,319,657 )

How can I increase my downloads?

Monthly downloads

My notes

Sign in to use this feature