Randomised placebo-controlled trials and HIV-infected pregnant women in developing countries. Ethical imperialism or unethical exploitation

Bioethics 15 (4):289–311 (2001)
In this paper, I provide a brief summary of the context, outline the arguments for and against the controversial use of placebo controls, and focus on particular areas that I believe merit further discussion or clarification. On balance, I argue that the researchers failed in their duties to protect the best interests of their research subjects, and to promote distributive justice. I discuss the difficulties of obtaining valid consent in this research context, and argue that it is unethical to inform women of their 'HIV' status without at least offering them prophylactic treatment for their unborn children. (edited).
Keywords info:mesh/Infectious Disease Transmission, Vertical  info:mesh/Informed Consent  info:mesh/Social Justice  info:mesh/Ethical Analysis  info:mesh/Pregnancy  info:mesh/Internationality  info:mesh/Research Design  info:mesh/Humans  info:mesh/Developing Countries  info:mesh/Placebos  info:mesh/Randomized Controlled Trials as Topic  info:mesh/Pregnant Women  info:mesh/HIV Infections  info:mesh/Female  info:mesh/Helsinki Declaration  info:mesh/Zidovudine  info:mesh/Ethics, Research  info:mesh/Human Experimentation  Humans   HIV Infections   Zidovudine   Placebos   Human Experimentation   Pregnancy   Research Design   Internationality   Developing Countries   Informed Consent   Social Justice   Ethical Analysis   Helsinki Declaration   Ethics, Research   Pregnant Women   Female   Randomized Controlled Trials as Topic   Infectious Disease Transmission, Vertical
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DOI 10.1111/1467-8519.00240
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