Ethical considerations for HIV cure-related research at the end of life

BMC Medical Ethics 19 (1):83 (2018)
  Copy   BIBTEX

Abstract

The U.S. National Institute of Allergies and Infectious Diseases and the National Institute of Mental Health have a new research priority: inclusion of terminally ill persons living with HIV in HIV cure-related research. For example, the Last Gift is a clinical research study at the University of California San Diego for PLWHIV who have a terminal illness, with a prognosis of less than 6 months. As end-of-life HIV cure research is relatively new, the scientific community has a timely opportunity to examine the related ethical challenges. Following an extensive review of the EOL and HIV cure research ethics literature, combined with deliberation from various stakeholders and our experience with the Last Gift study to date, we outline considerations to ensure that such research with terminally ill PLWHIV remains ethical, focusing on five topics: 1) protecting autonomy through informed consent, 2) avoiding exploitation and fostering altruism, 3) maintaining a favorable benefits/risks balance, 4) safeguarding against vulnerability through patient-participant centeredness, and 5) ensuring the acceptance of next-of-kin/loved ones and community stakeholders. EOL HIV cure-related research can be performed ethically and effectively by anticipating key issues that may arise. While not unique to the fields of EOL or HIV cure-related research, the considerations highlighted can help us support a new research approach. We must honor the lives of PLWHIV whose involvement in research can provide the knowledge needed to achieve the dream of making HIV infection curable.

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 74,389

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Informed Consent to HIV Cure Research.Danielle Bromwich & Joseph R. Millum - 2017 - Journal of Medical Ethics 43 (2):108-113.
The Return of Results of Deceased Research Participants.Anne Marie Tassé - 2011 - Journal of Law, Medicine and Ethics 39 (4):621-630.
Ethics in Neonatal Pain Research.Anna Axelin & Sanna Salanterä - 2008 - Nursing Ethics 15 (4):492-499.
Selecting the Right Tool For the Job.Arthur L. Caplan, Carolyn Plunkett & Bruce Levin - 2015 - American Journal of Bioethics 15 (4):4-10.

Analytics

Added to PP
2018-10-21

Downloads
15 (#692,594)

6 months
1 (#415,900)

Historical graph of downloads
How can I increase my downloads?