Unintended Changes in Cognition, Mood, and Behavior Arising from Cell-Based Interventions for Neurological Conditions: Ethical Challenges

American Journal of Bioethics 9 (5):31-36 (2009)

Authors
Peter R. King
Nottingham University (PhD)
Abstract
The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
ISBN(s)
DOI 10.1080/15265160902788645
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 46,405
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

Thinking About the Human Neuron Mouse.Henry T. Greely, Mildred K. Cho, Linda F. Hogle & Debra M. Satz - 2007 - American Journal of Bioethics 7 (5):27 – 40.
At the Edge of Humanity: Human Stem Cells, Chimeras, and Moral Status.Robert Streiffer - 2005 - Kennedy Institute of Ethics Journal 15 (4):347-370.

View all 7 references / Add more references

Citations of this work BETA

Criteria for Authorship in Bioethics.David B. Resnik & Zubin Master - 2011 - American Journal of Bioethics 11 (10):17 - 21.

View all 10 citations / Add more citations

Similar books and articles

Towards a Computational Theory of Mood.Laura Sizer - 2000 - British Journal for the Philosophy of Science 51 (4):743-770.

Analytics

Added to PP index
2010-09-14

Total views
38 ( #238,135 of 2,286,200 )

Recent downloads (6 months)
7 ( #156,917 of 2,286,200 )

How can I increase my downloads?

Downloads

My notes

Sign in to use this feature