Bioessays 40 (2):1700148 (2018)

Abstract
Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine. Epigenetic and transcriptional variability mediate phenotypic plasticity, enabling adaptation to changing environments. In this review, we describe the sources of inter- and intra-individual variability and discuss epigenetic regulators of gene expression variability, including DNA methylation and chromatin structure. Understanding these molecular mechanisms will improve therapeutic approaches and personalized medicine.
Keywords 3D chromatin structure  DNA methylation  biological noise  chromatin  epigenetics  gene expression  genome architecture  heterogeneity  transcription  variability
Categories (categorize this paper)
DOI 10.1002/bies.201700148
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 57,138
Through your library

References found in this work BETA

Add more references

Citations of this work BETA

Add more citations

Similar books and articles

Evolution of Phenotypic Plasticity: Where Are We Going Now?Massimo Pigliucci - 2005 - Trends in Ecology and Evolution 20 (9):481-486.
The Evolution of Phenotypic Plasticity: Genealogy of a Debate in Genetics.Antonine Nicoglou - 2015 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 50:67-76.

Analytics

Added to PP index
2017-12-19

Total views
23 ( #452,118 of 2,411,685 )

Recent downloads (6 months)
1 ( #539,172 of 2,411,685 )

How can I increase my downloads?

Downloads

My notes