American Journal of Bioethics 18 (10):35-42 (2018)

As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans.
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DOI 10.1080/15265161.2018.1513584
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References found in this work BETA

Selecting the Right Tool For the Job.Arthur L. Caplan, Carolyn Plunkett & Bruce Levin - 2015 - American Journal of Bioethics 15 (4):4-10.
The Ebola clinical trials: a precedent for research ethics in disasters.P. Calain - 2017 - Journal of Medical Ethics Recent Issues 44 (1):3-8.
One Health, Vaccines and Ebola: The Opportunities for Shared Benefits.Benjamin Capps & Zohar Lederman - 2015 - Journal of Agricultural and Environmental Ethics 28 (6):1011-1032.

View all 7 references / Add more references

Citations of this work BETA

More Risky Than Radical.Lori Gruen - 2018 - American Journal of Bioethics 18 (10):45-47.
One Health Ethics: A Response to Pragmatism.Zohar Lederman & Benjamin Capps - 2020 - Journal of Medical Ethics 46 (9):632-633.

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