Henry Dale, histamine and anaphylaxis: Reflections on the role of chance in the history of allergy
Studies in History and Philosophy of Science Part C 34 (3):455-472 (2003)
The role of the Nobel Laureate Henry Dale (1875-1968) in the history of allergy and the association of anaphylactic conditions with the liberation of histamine is often overlooked. This paper examines his work in this field in the broader context of his researches into endogenous mediators of normal physiological and abnormal pathological functioning. It also assesses the impact of his working environment, especially the unique conditions he enjoyed at the beginning of the twentieth century in the Wellcome Physiological Research Laboratories (WPRL). The WPRL belonged to the pharmaceutical manufacturer Henry Wellcome, and it was the juxtaposition of the routine commercial obligation of testing drugs for Burroughs, Wellcome & Co., with the opportunities of pursuing unfettered physiological research in well-equipped and supported laboratories, that resulted in what Dale referred to as 'happy accidents' when one set of results suggested experimental strategies and designs to another circumstance. In this way an observation of an unusual effect of an extract of ergot of rye led to collaborative chemical and physiological explorations which revealed the presence of histamine, previously known only as a synthetic product. Further work, accidentally facilitated by the fact that the WPRL produced serum anti-toxins commercially and surplus horse serum was used in experiments where other physiologists routinely used saline, hinted that histamine played a role in the symptom complex known as anaphylaxis. This paper explores some of these themes and elaborates their significance.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Exemplars, Records, Tools: Organisms in Botanical Research, C. 1750-1850.Staffan Mueller-Wille - unknown
The Changing Signiﬁcance of Chance Experiments in Technological Development.Matthias Adam - manuscript
'Trouble From Within': Allergy, Autoimmunity, and Pathology in the First Half of the Twentieth Century.O. Parnes - 2003 - Studies in History and Philosophy of Science Part C 34 (3):425-454.
Reflections on the History and Ethics of the Proper Attribution and Misappropriation of Merit.Henry Gans - 2011 - Perspectives in Biology and Medicine 54 (4):470-478.
Pictures, Preparations, and Living Processes: The Production of Immediate Visual Perception (Anschauung) in Late-19th-Century Physiology. [REVIEW]Henning Schmidgen - 2004 - Journal of the History of Biology 37 (3):477 - 513.
Natural History and the Clinic: The Regional Ecology of Allergy in America.G. Mitman - 2003 - Studies in History and Philosophy of Science Part C 34 (3):491-510.
John Freeman, Hay Fever and the Origins of Clinical Allergy in Britain, 1900-1950.M. Jackson - 2003 - Studies in History and Philosophy of Science Part C 34 (3):473-490.
On Guinea Pigs, Dogs and Men: Anaphylaxis and the Study of Biological Individuality, 1902-1939.I. Lowy - 2003 - Studies in History and Philosophy of Science Part C 34 (3):399-423.
Henry Dale, Histamine and Anaphylaxis: Reflections on the Role of Chance in the History of Allergy.E. M. Tansey - 2003 - Studies in History and Philosophy of Science Part C 34 (3):455-472.
Added to index2009-01-28
Total downloads7 ( #508,984 of 2,146,220 )
Recent downloads (6 months)1 ( #387,123 of 2,146,220 )
How can I increase my downloads?
There are no threads in this forum
Nothing in this forum yet.