Acta Biotheoretica 34 (1):53-80 (1985)
Proteins with nearly the same structure and function (homologous proteins) are found in increasing numbers in phylogenetically different, even very distant taxa (e.g. hemoglobins in vertebrates, in some invertebrates, and even in certain plants). In discussing the origin of those proteins biologists hardly at all consider convergent evolution because the origin of proteins is held to be a random process, at least ultimately, since selection can work only what the random process delivers as having a minimum adaptive value. The repetition of a random process with the same result is considered to be extremely unlikely. The supposed (un)likelihood, however, is almost never determined quantitatively. This paper attempts such a quantitative determination. It appears that the probability for the random origin of a definite protein is greater than what one would expect in view of the enormous number of equally possible nucleotide sequences in the corresponding gene since what is equally possible is not always equally likely. The probability, however, of the convergent evolution of two proteins with approximately the same structure and function is too low to be plausible, even when all possible circumstances are present which seem to heighten the likelihood of such a convergence. If this is so, then the plausibility of a random evolution of two or more different but functionally related proteins seems hardly greater.
|Keywords||No keywords specified (fix it)|
No categories specified
(categorize this paper)
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Support Vector Machines for Predicting Apoptosis Proteins Types.Jing Huang & Feng Shi - 2005 - Acta Biotheoretica 53 (1):39-47.
Concept of Immunomics: A New Frontier in the Battle for Gene Function?Jan Klysik - 2001 - Acta Biotheoretica 49 (3):191-202.
Explanatory Loops and the Limits of Genetic Reductionism.Martin Carrier & Patrick Finzer - 2006 - International Studies in the Philosophy of Science 20 (3):267 – 283.
Framework for a Protein Ontology.Darren A. Natale, Cecilia N. Arighi, Winona Barker, Judith Blake, Ti-Cheng Chang, Zhangzhi Hu, Hongfang Liu, Barry Smith & Cathy H. Wu - 2007 - BMC Bioinformatics, Nov. 2007, 8(Suppl. 9) 8 (9):S1.
Structure, Function, and Protein Taxonomy.William Goodwin - 2011 - Biology and Philosophy 26 (4):533-545.
The Mechanical Properties of Proteins Determine the Laws of Evolutionary Change.I. Walker - 1979 - Acta Biotheoretica 28 (4):239-282.
Protein Folding and Evolution Are Driven by the Maxwell Demon Activity of Proteins.Alejandro Balbín & Eugenio Andrade - 2004 - Acta Biotheoretica 52 (3):173-200.
Added to index2009-01-28
Total downloads21 ( #232,268 of 2,153,332 )
Recent downloads (6 months)4 ( #185,045 of 2,153,332 )
How can I increase my downloads?