Stakeholder perspectives on ethical challenges in hiv vaccine trials in south Africa
Zaynab Essack, Jennifer Koen, Nicola Barsdorf, Catherine Slack, Michael Quayle, Cecilia Milford, Graham Lindegger, Chitra Ranchod & Richard Mukuka
Developing World Bioethics 10 (1):11-21 (2010)
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Abstract |
There is little published literature on the ethical concerns of stakeholders in HIV vaccine trials. This study explored the ethical challenges identified by various stakeholders, through an open-ended, in-depth approach. While the few previous studies have been largely quantitative, respondents in this study had the opportunity to spontaneously identify the issues that they perceived to be of priority concern in the South African context. Stakeholders spontaneously identified the following as ethical priorities: informed consent, social harms, collaborative relationships between research stakeholders, the participation of children and adolescents, access to treatment for participants who become infected with HIV, physical harms, fair participant and community selection, confidentiality, benefits, and payment. While there is some speculation that research in developing countries poses special ethical challenges, overall no issues were identified that have not been anticipated in international guidance, literature and popular frameworks. However, the South African context affords a distinctive gloss to these expected issues; for example, respondents were concerned that the predominant selection of black participants may perpetuate racist practices of apartheid. Stakeholders should be aware of contextual factors impacting on the implementation of ethical principles. We make a series of recommendations for South African trials, including amendments to the ethical-legal framework and research policies, and, for further research.
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Keywords | stakeholder perspectives developing countries South Africa ethics ethical concerns HIV vaccine trials |
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DOI | 10.1111/j.1471-8847.2009.00254.x |
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Citations of this work BETA
For-Profit Clinical Trials in Developing Countries—Those Troublesome Patient Benefits.Udo Schuklenk - 2010 - American Journal of Bioethics 10 (6):52-54.
Informed Consent for HIV Cure Research in South Africa: Issues to Consider.Ciara Staunton - 2015 - BMC Medical Ethics 16 (1):3.
Human Dignity as a Basis for Providing Post-Trial Access to Healthcare for Research Participants: A South African Perspective.Pamela Andanda & Jane Wathuta - 2018 - Medicine, Health Care and Philosophy 21 (1):139-155.
Stakeholder Views of Ethical Guidance Regarding Prevention and Care in HIV Vaccine Trials.Rika Moorhouse, Catherine Slack, Michael Quayle, Zaynab Essack & Graham Lindegger - 2014 - BMC Medical Ethics 15 (1):51.
Ensuring Consent to Research is Voluntary: How Far Do We Need to Go?Susan Bull & Graham Charles Lindegger - 2011 - American Journal of Bioethics 11 (8):27-29.
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