Mitochondrial replacement therapy: Cautiously replace the master manipulator

Bioessays 37 (6):584-585 (2015)

Abstract
Mitochondria, the powerhouses of our cells, are essential to life. Normal mitochondrial function is achieved through the cooperative interaction of the nuclear and mitochondrial genomes. New IVF approaches intended to circumvent devastating mitochondrial disease look set to change the ancient pattern of mtDNA inheritance and interaction with unknown consequences.
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DOI 10.1002/bies.201500008
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