Infectivity of ribonucleic acid from Tobacco Mosaic Virus

Nature 177:702-703 (1956)

Alfred Gierer
Max-Planck-Institute of Developmental Biology, Tuebingen, Germany
Upon separation of the protein from the nucleic acid component of tobacco mosaic virus by phenol, using a fast and gentle procedure, the nucleic acid is infective in assays on tobacco leaves. A series of qualitative and quantitative control experiments demonstrates that the biological activity cannot depend on residual proteins in the preparation, but is a property of isolated nucleic acid which is thus the genetic material of the virus.
Keywords virus  infectivity  ribonucleic acid  genetic material  tobacco mosaic virus
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The Hydra Model - a Model for What?Alfred Gierer - 2012 - International Journal of Developmental Biology 56:437-445.
What is a Virus? The Case of Tobacco Mosaic Disease.Ton van Helvoort - 1991 - Studies in History and Philosophy of Science Part A 22 (4):557-588.
Experiment, Difference, and Writing: II. The Laboratory Production of Transfer RNA.Hans-Jörg Rheinberger - 1991 - Studies in History and Philosophy of Science Part A 23 (3):389-422.
Predictive Hypotheses Are Ineffectual in Resolving Complex Biochemical Systems.Michael Fry - 2018 - History and Philosophy of the Life Sciences 40 (2):25.

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