Infectivity of ribonucleic acid from Tobacco Mosaic Virus

Nature 177:702-703 (1956)
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Abstract

Upon separation of the protein from the nucleic acid component of tobacco mosaic virus by phenol, using a fast and gentle procedure, the nucleic acid is infective in assays on tobacco leaves. A series of qualitative and quantitative control experiments demonstrates that the biological activity cannot depend on residual proteins in the preparation, but is a property of isolated nucleic acid which is thus the genetic material of the virus.

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Alfred Gierer
Max-Planck-Institute of Developmental Biology, Tuebingen, Germany

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