Biological Theory 6 (1):65-72 (2011)

Developmental biology is expanding into several new areas. One new area of study concerns the production of adult-onset phenotypes by exposure of the fetus or neonate to environmental agents. These agents include maternal nutrients, developmental modulators, and maternal care. In all three cases, a major mechanism for the generation of the altered phenotype is chromatin modification. Nutrient conditions, developmental modulators, and even maternal care appear to alter DNA methylation and other associated changes in chromatin that regulate gene expression. This brings a new, under-appreciated, dimension of gene regulation into developmental biology, and it also demonstrates the poverty of the nature versus nurture framework for discussing phenotype production. Moreover, while such epigenetic mechanisms undermine genetic determinism, they add a layer of probabilistic biological causality for the maintenance of social inequalities.
Keywords Behavior  Development  Developmental origins of adult disease  Environmental causation  Epigenetic  Nature–nurture  Nutrition  Plasticity
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DOI 10.1007/s13752-011-0008-0
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Development and Aging.Michel Morange - 2011 - Biological Theory 6 (1):59-64.

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Development and Aging.Michel Morange - 2011 - Biological Theory 6 (1):59-64.
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